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Fig. 1 | BMC Cancer

Fig. 1

From: Complex interactions of lovastatin with 10 chemotherapeutic drugs: a rigorous evaluation of synergism and antagonism

Fig. 1

Graphical representation of three global metrics calculated by the Combenefit software for each of the ten dual-drug assays conducted with the S. cerevisiae heterozygous-deletion pool. a. The SUM_SYN_ANT metric, defined as the “sum of synergy and antagonism observed in concentration logarithmic space” [45], is depicted for the ten drug combinations on day two. The blue bars denote drug combinations with net synergism,; the red bars, net antagonism; and the grey bars, neutral scores. b. A comparison of SUM_SYN_ANT scores on Day 3 versus Day 2. In most, but not all instances (see text), the scores tended toward less synergism and/or greater antagonism on Day 3. c. The SYN_MAX metric (defined as the “maximum synergy observed”) on Day 2; the drug combinations are listed in the same order as in (a). Standard deviations, as recorded by the software on the synergy level matrices for the Lowe model, are indicated. d. The ANT_MAX metric (“maximum antagonism observed”) and standard deviations on Day 2. The values in (c) and (d) represent single maximal values whereas the SUM_SYN_ANT metric encompasses all values within the concentration space

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