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Table 3 Possible predictor for level VI metastasis in male patients with oral squamous cell carcinoma at the floor of mouth

From: Central neck lymph node metastasis in oral squamous cell carcinoma at the floor of mouth

Variables level VI metastasis p
Positive (n = 13) Negative (n = 329)
Age
 <40 years 0 30 (9.1%)  
  ≥ 40 years 13 (100%) 299 (90.9%) 0.392
cT stage
 T1 + T2 0 157 (47.7%)  
 T3 + T4 13 (100%) 172 (52.3%) 0.001
cN
 N0 0 150 (45.6%)  
 N1 + N2 9 (69.2%) 146 (44.4%)  
 N3 4 (30.8%) 33 (10.3%) 0.002
PNIa,d
 Positive 6 (46.2%) 66 (20.1%)  
 Negative 7 (53.8%) 198 (60.2%) 0.107
LVIb,e
 Positive 9 (69.2%) 50 (15.2%)  
 Negative 4 (30.8%) 210 (63.8%) < 0.001
Differentiation
 Well 3 (23.1%) 148 (45.0%)  
 Moderate 5 (38.5%) 115 (35.0%)  
 Poor 5 (38.5%) 66 (20.1%) 0.210
ENEc, f
 Positive 13 (100%) 25 (7.6%)  
 Negative 0 199 (60.5%) < 0.001
  1. a PNI perineural invasion, b LVI lymphovascular invasion, c ENE extranodal extension
  2. d Status of PNI in 65 (19.8%) patients remained unknown;
  3. e Status of LVI in 69 (21.0%) patients remained unknown;
  4. f Status of ENE in 105 (31.9%) patients remained unknown