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Table 3 Comparison of penetration depth of doxorubicin after PIPAC with a pressure at 12 mmHg (group12) and PIPAC with a pressure at 20 mmHg (group20)

From: Pressurized intra-peritoneal aerosol chemotherapy (PIPAC): increased intraperitoneal pressure does not affect distribution patterns but leads to deeper penetration depth of doxorubicin in a sheep model

Peritoneum

Group 12

(12 mmHg)

n/N (%)

Group 20

(20 mmHg)

n/N (%)

p-value

34/95

(36)

23/82

(28)

0.69

P1

4/9

(44)

1/16

(6)

0.08

P2

0/11

(0)

10/20

(50)

*

P3

9/10

(90)

3/11

(27)

0.11

P4

16/24

(67)

3/10

(30)

0.38

P5

5/19

(26)

5/17

(29)

0.79

P6

0/22

(0)

1/8

(13)

*

Ovary

6/11

(55)

15/15

(100)

*

Omentum

20/20

(100)

26/26

(100)

*

Caecum

2/9

(22)

8/8

(100)

*

  1. n = number of samples showing a penetration depth > 100 μm
  2. N = number of samples showing presence of doxorubicin
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BMC Cancer

ISSN: 1471-2407

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