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Table 1 Demographic and disease-related characteristics among patients with or without ADRs (univariate logistic regression)

From: Adverse reactions of targeted therapy in cancer patients: a retrospective study of hospital medical data in China

Characteristics   Cases, n (%) ADR OR a (95%CI) P value
With, (%) Without, n (%)
All   485 (100) 296 (61.0) 189 (39.0)   
Age: Mean (SD)   63.4 (11.8) 67.8 (12.6) 59.5 (11.3)   
Age ≥60 294 (60.6) 202 (68.2) 92 (48.7) 3.247 [1.564–7.681] 0.014*
<60 191 (39.4) 94 (31.8) 97 (51.3) 1  
Sex Male 261 (53.8) 161 (54.4) 100 (52.9) 1.014 [0.386–1.714] 0.325
Female 224 (46.2) 135 (45.6) 89 (47.1) 1  
Education Level College and above 155 (32) 77 (26) 78 (41.3) 0.713 [0.431–0.950] 0.017*
High school and below 330 (68) 219 (74) 111 (58.7) 1  
Place of residence Urban 194 (40) 114 (38.5) 80 (42.3) 2.192 [0.689–5.237] 0.189
Rural 291 (60) 182 (61.5) 109 (57.7) 1  
Family income (Yuan)/M >10,000 56 (11.5) 35 (11.8) 21 (11.1) 1.885 [0.332–6.457] 0.846
5001 ~ 10,000 227 (46.8) 133 (44.9) 94 (49.7) 0.912 [0.420–1.518] 0.092
3001 ~ 5000 175 (36.1) 113 (38.2) 62 (32.8) 3.817 [0.774–9.220] 0.332
<3000 27 (5.6) 15 (5.1) 12 (6.3) 1  
Primary cancer Lung 122 (25.2) 88 (29.7) 34 (18) 3.892 [1.521–10.109] 0.008**
Renal 86 (17.7) 59 (19.9) 27 (14.3) 1.732 [0.458–6.256] 0.122
Gastric 49 (10.1) 22 (7.4) 27 (14.3) 3.069 [1.746–9.961] 0.007**
Colorectal 53 (11) 23 (7.8) 30 (15.9) 3.549 [1.472–9.135] 0.006**
Breast 89 (18.4) 59 (19.9) 30 (15.9) 1.776 [0.753–3.158] 0.084
Non-Hodgkin’s Lymphoma 56 (11.5) 34 (11.6) 22 (11.6) 4.711 [0.843–7.953] 0.569
Others 30 (6.2) 11 (3.7) 19 (10) 1  
Medical insurance Yes 383 (79) 231 (78) 152 (80.4) 3.791 [0.654–7.824] 0.264
No 102 (21) 65 (22) 37 (19.6) 1  
CCI >2 240 (49.5) 178 (60.1) 62 (32.8) 4.139 [1.418–7.027] 0.003**
≤2 245 (50.5) 118 (39.9) 127 (67.2) 1  
Duration of medicine ≤3 months 262 (54) 98 (33.1) 164 (62.1) 0.647 [0.463–0.815] 0.004**
>3 months 223 (46) 198 (66.9) 25 (37.9) 1  
Combination of medicine Yes 286 (59) 201 (67.9) 85 (45) 1.736 [1.486–4.153] 0.028*
No 199 (41) 95 (32.1) 104 (55) 1  
Route of administration Intravenous 209 (43.1) 164 (55.4) 45 (23.8) 3.128 [2.066–7.550] 0.007**
Oral 179 (36.9) 100 (33.8) 79 (41.8) 1.806 [0.538–6.872] 0.075
Subcutaneous 65 (13.4) 25 (8.4) 40 (21.2) 1.257 [0.296–1.836] 0.066
Intrathecal 7 (1.4) 3 (1.0) 4 (2.1) 2.129 [0.588–4.967] 0.125
Intraperitoneal 25 (5.2) 4 (1.4) 21 (1.1) 1  
  1. Abbreviations: ADR, adverse reactions; CCI, Charlson Comorbidity Index
  2. # Unmarried = single, divorced, and widow;
  3. * P values are statistically significant
  4. a Binary logistic regression models were computed for each characteristic separately and the ADR was included as an independent variable
  5. *P<0.05, **P<0.01