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Table 3 Univariate and multivariate analysis of OS

From: Prognostic impact of additive chemotherapy after curative resection of metachronous colorectal liver metastasis: a single-centre retrospective study

  Number of patients Median OS, months Univariate analysis Multivariate analysis
p value HR 95% CI p value HR 95% CI
Primary tumor
 Colon 44 62 0.58 1.18 0.65–2.18    
 Rectum 31 53       
Primary nodal status
 N0 31 65 0.16 1.50 0.86–2.64    
 N1/2 43 51       
Time between primary and hepatic resection
  < 12 months 27 57 0.18 0.65 0.34–1.23    
  > 12 months 48 75       
Number of CRLM
  < 5 70 62 0.012 3.86 1.35–11.05 0.026 3.46 1.16–10.32
  > 5 4 19       
Size of greatest CRLM
  < 5 cm 62 62 0.21 1.83 0.71–4.71    
  > 5 cm 9 27       
Neoadjuvant CTx
 No 62 62 0.30 0.63 0.26–1.51    
 Yes 13 68       
Additive CTx
 No 41 57 0.032 0.50 0.26–0.94 0.016 0.44 0.23–0.86
 Yes 34 62       
CEA, ng/ml
  < 70 47 65 0.031 4.24 1.14–15.74    
  > 70 5 22       
Disease recurrence
 Yes 48 51 0.006 2.65 1.32–5.36 0.009 2.70 1.29–5.65
 No 27 110