Table 3 Univariate and multivariate analysis of OS
Number of patients | Median OS, months | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|---|
p value | HR | 95% CI | p value | HR | 95% CI | |||
Primary tumor | ||||||||
Colon | 44 | 62 | 0.58 | 1.18 | 0.65–2.18 | |||
Rectum | 31 | 53 | ||||||
Primary nodal status | ||||||||
N0 | 31 | 65 | 0.16 | 1.50 | 0.86–2.64 | |||
N1/2 | 43 | 51 | ||||||
Time between primary and hepatic resection | ||||||||
< 12 months | 27 | 57 | 0.18 | 0.65 | 0.34–1.23 | |||
> 12 months | 48 | 75 | ||||||
Number of CRLM | ||||||||
< 5 | 70 | 62 | 0.012 | 3.86 | 1.35–11.05 | 0.026 | 3.46 | 1.16–10.32 |
> 5 | 4 | 19 | ||||||
Size of greatest CRLM | ||||||||
< 5 cm | 62 | 62 | 0.21 | 1.83 | 0.71–4.71 | |||
> 5 cm | 9 | 27 | ||||||
Neoadjuvant CTx | ||||||||
No | 62 | 62 | 0.30 | 0.63 | 0.26–1.51 | |||
Yes | 13 | 68 | ||||||
Additive CTx | ||||||||
No | 41 | 57 | 0.032 | 0.50 | 0.26–0.94 | 0.016 | 0.44 | 0.23–0.86 |
Yes | 34 | 62 | ||||||
CEA, ng/ml | ||||||||
< 70 | 47 | 65 | 0.031 | 4.24 | 1.14–15.74 | |||
> 70 | 5 | 22 | ||||||
Disease recurrence | ||||||||
Yes | 48 | 51 | 0.006 | 2.65 | 1.32–5.36 | 0.009 | 2.70 | 1.29–5.65 |
No | 27 | 110 | ||||||