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Table 2 Univariate and multivariate analysis of DFS

From: Prognostic impact of additive chemotherapy after curative resection of metachronous colorectal liver metastasis: a single-centre retrospective study

  Number of patients Median DFS, months Univariate analysis Multivariate analysis
p value HR 95% CI p value HR 95% CI
Primary tumor
 Colon 44 36 0.14 1.53 0.87–2.68    
 Rectum 31 18       
Primary nodal status
 N0 31 37 0.034 1.73 1.04–2.88 0.008 2.01 1.20–3.34
 N1/2 43 14       
Time between primary and hepatic resection
  < 12 months 27 14 0.11 0.63 0.35–1.12    
  > 12 months 48 28       
Number of CRLM
  < 5 70 28 0.005 4.58 1.58–13.26 0.001 6.49 2.15–19.61
  > 5 4 7.5    
Size of greatest CRLM
  < 5 cm 62 20 0.27 1.62 0.68–3.82    
  > 5 cm 9 29       
Neoadjuvant CTx
 No 62 20 0.62 0.83 0.39–1.76    
 Yes 13 28       
Additive CTx
 No 41 18 0.29 0.74 0.42–1.29    
 Yes 34 29       
CEA, ng/ml
  < 70 47 28 0.70 0.76 0.18–3.19    
  > 70 5 19.5