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Table 3 Distribution of HR-HPV combinations by histological grade stratified by the number of concurrent infections (Guadeloupe, 2014–2016)

From: Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe

  1 virus infection   2–3 virus infections   > 3 virus infections  
CIN2/3 Invasive cancers CIN2/3 Invasive cancers CIN2/3 Invasive cancers  
N = 32 N = 2 p n = 49 n = 17 p n = 81 n = 7 p
HR-HPV combinations, n(%)
 1HR 29 2   19 8   0 0  
 HPV16 20 (69) 2 (100) 0.28 11 (22) 4 (24) 1 0 0  
 HPV33 1 (3.4) 0 (0) 0.80 0 0     
 HPV35 7 (24) 0 (0) 0.45 1 (2) 2 (12) 0.16 0 0  
 HPV51 1 (3.4) 0 (0) 0.80 5 (4) 2 (12) 1 0 0  
 HPV56 2 (4) 0 (0) 1 0 0  
2 or 3 HR   29 9   51 2  
 HPV16 + 1 other HR * 5 (10) 1 (6) 1 3 (4) 0 (0) 1
 HPV[18–56] 1 (2) 2 (12) 0.16 2 (2) 0 (0) 1
 HPV[31–33] + 1 other HR 4 (8) 2 (12) 0.64 32 (40) 1 (14) 0.25
 HPV [31–52] + 1 other HR 14 (29) 1 (6) 0.09 6 (7) 1 (14) 0.45
 HPV[39–45] + HPV68 2 (4) 1 (6) 1 2 (2) 0 (0) 1
More than 3 HR 29 5  
 HPV[31–33] + 2 or more other HR * 19 (23) 4 (57) 0.07
 HPV{16–52] + 2 or more other HR * 4 (5) 0 (0) 1
 HPV[39–68] + 2 or more other HR* 4 (5) 0 (0) 1
 HPV[33–52–58-68] 3 (4) 0 (0) 1
  1. Other HR-HPV found in association with theses main combinations, involved 2 or 3 of the following HPV genotypes: 18, 35, 45, 51, 56, 58, 59, 68