Table 3 Logistic regression model for use of antidepressants, sedatives and anti-epileptics, respectively, at one year following index date, for patients with LGG

 Index year (per year)

1.22 (1.07-1.39)

0.002**

1.31 (1.11-1.55)

0.002**

 Female (vs. male)

2.99 (1.60-5.60)

0.001**

3.41 (1.71-6.80)

0.001**

 Age (per year)

1.02 (1.00-1.05)

0.027*

1.02 (1.00-1.05)

0.11

 Income (per 100.000 SEK)

0.96 (0.76-1.20)

0.69

1.07 (0.83-1.39)

0.60

 Higher education (vs. lower education)

0.94 (0.78-1.15)

0.56

0.97 (0.78-1.21)

0.78

 History of depression

7.61 (3.88-14.94)

<0.001***

6.12 (2.96-12.63)

<0.001***

 Use of antidepressants preoperatively

14.15 (5.88-34.08),

<0.001***

 Elixhauser comorbidity index (0, 1, 2, >3)

1.33 (0.96-1.84)

0.09

1.09 (0.75-1.59)

0.65

 Functional level (per WHO performance status category)

0.98 (0.92-1.03)

0.38

0.96 (0.88-1.06)

0.42

 Tumour size (6)

1.08 (0.96-1-21)

0.22

0.92 (0.79-1.07)

0.30

 Index year (per year)

1.13 (0.99-1.29)

0.07

1.12 (0.97-1.30)

0.14

 Female (vs. male)

1.23 (0.66-2.30)

0.51

1.13 (0.58-2.19)

0.73

 Age (per year)

1.02 (1.00-1.04)

0.09

1.02 (0.99-1.04)

0.24

 Income (per 100.000 SEK)

0.87 (0.67-1.13)

0.30

0.90 (0.62-1.22)

0.49

 Higher education (vs. lower education)

0.81 (0.66-1.00)

0.05

0.90 (0.71-1.13)

0.35

 History of anxiety and/or sleeping difficulties

2.58 (1.36-4.90)

0.004**

2.14 (1.09-4.20)

0.027*

 use of sedatives preoperatively

3.05 (1.60-5.82),

<0.001***

 Elixhauser comorbidity index (0, 1, 2, >3)

1.37 (0.98-1.92)

0.07

1.17 (0.80-1.70)

0.41

 Functional level (per WHO performance status category)

0.97 (0.91-1.04)

0.42

0.97 (0.89-1.05)

0.43

 Tumour size (6)

1.09 (0.97-1.23)

0.17

1.00 (0.87-1.16)

0.98

 Index year (per year)

1.13 (0.99-1.29)

0.07

1.12 (0.97-1.30)

0.14

 Female (vs. male)

1.23 (0.66-2.30)

0.51

1.13 (0.58-2.19)

0.73

 Age (per year)

1.02 (1.00-1.04)

0.09

1.02 (0.99-1.04)

0.24

 Income (per 100.000 SEK)

0.87 (0.67-1.13)

0.30

0.90 (0.62-1.22)

0.49

 Higher education (vs. lower education)

0.81 (0.66-1.00)

0.05

0.90 (0.71-1.13)

0.35

 History of anxiety and/or sleeping difficulties

2.58 (1.36-4.90)

0.004**

2.14 (1.09-4.20)

0.027*

 use of AED preoperatively

9.49 (6.07 – 14.85),

<0.001***

 Elixhauser comorbidity index (0, 1, 2, >3)

1.37 (0.98-1.92)

0.07

1.17 (0.80-1.70)

0.41

 Functional level (per WHO performance status category)

0.97 (0.91-1.04)

0.42

0.97 (0.89-1.05)

0.43

 Tumour size (6)

1.09 (0.97-1.23)

0.17

1.00 (0.87-1.16)

0.98