Table 2 Summary of CAR-T parameters in tissues and whole blood (Mean)
From: Distribution of chimeric antigen receptor-modified T cells against CD19 in B-cell malignancies
| Â | Tmax | Cmax | AUC0-1344h |
|---|---|---|---|
Tissue | h | {copies/μg} | h*{copies/μg} |
Heart | 1008 | 8290.2 | 3,165,207.4 |
Liver | 1008 | 30,327.7 | 14,164,836.0 |
Spleen | 1344 | 39,484.9 | 22,287,294.0 |
Lung | 1008 | 39,389.1 | 20,603,898.0 |
Kidney | 1008 | 23,099.1 | 9,489,641.0 |
Brain | 1008 | 3892.4 | 1,581,518.5 |
Uterus | 1344 | 9159.5 | 1,538,796.4 |
Testis | 1008 | 26,255.8 | 9,344,230.5 |
Ovary | 1344 | 2157.9 | 362,522.2 |
Epididymis | 1008 | 37,075.9 | 14,626,642.0 |
Stomach | 1008 | 43,912.5 | 15,893,940.0 |
Duodenum | 1008 | 15,141.3 | 5,315,737.1 |
Fat | 1008 | 45,655.4 | 17,008,538.0 |
muscle | 1008 | 34,794.5 | 11,934,449.0 |
Colon | 1008 | 8374.4 | 2,996,989.2 |
Blood | 0.083 | 33,905.6 | 6,448,893.4 |
Bone marrow | 1344 | 8535.2 | 4,017,144.8 |