Table 4 Salivary Interleukin 1β in oral cancer
From: Salivary cytokines as biomarkers of oral cancer: a systematic review and meta-analysis
Cytokine | Author | Year | Groups | Sample (n) | Mean ± SD (pg/ml) | Statistic test | P Value | AUC |
|---|---|---|---|---|---|---|---|---|
IL-1β | ELASHOFF, D. et al. | 2012 | Oral Cancer – cohort 5 | 31 | 293 ± 396 | Mann–Whitney U test and area under the curve (AUC) | < 0.05 | 0.570 |
Control - cohort 5 | 70 | 169 ± 202 | ||||||
ARELLANO-GARCIA, M.E. et al. | 2008 | Oral Cancer | 40 | 591.5 ± 618.7 | Student t-test, Pearson correlation coefficient; ROC curve and area under curv | With single-plex: 0.03 With multiplex: 0.04 | 0.840 (sensitivity = 63.9%; specificity = 100%) | |
Control Oral Cancer | 42 | 79.6 ± 578 | ||||||
KATAKURA A. et al. | 2007 | Oral Cancer | 19 | 158.9 | Two-tailed t-tests | < 0.05 | – | |
Control | 20 | 14.1 | ||||||
GLEBER-NETTO, FO. et al. | 2016 | Oral Cancer | 60 | 101.0 ± 113.0 | ANOVA (Kruskal - Wallis Test); Wilcoxon Two - Sample test | Oral Cancer x Control = p < 0.01; Oral Cancer x Maligmant Potencial = p < 0.004 | OPMD vs. Controls = 0.542 OSCC vs. Controls = 0.721 OSCC vs. OPMD = 0.569 | |
Malignant potentialy injuries | 60 | 39.7 ± 28.0 | ||||||
Control | 60 | 48.1 ± 42.0 | ||||||
LEE, L.T. et al. | 2018 | Oral Cancer | 41 | 391.4 ± 540.4 | Kolmogorov-Smirnov and Mann-Whitney | 0.002 | AUC: 0.729 (Sensitivity = 60.98%; Specificity = 79.17%; p = 0.0004) | |
Control | 24 | 132.5 ± 175.8 | ||||||
BRAILO, V. et al. | 2012 | Oral Cancer | 28 | 906.0 ± 62.2 | Smirnoff Kolmogorof and Kruskal Wallis | 0.000 | – | |
Leukoplakia | 29 | 143.0 ± 54.7 | ||||||
Control | 31 | 354.0 ± 61.4 |