Skip to main content

Table 4 Salivary Interleukin 1β in oral cancer

From: Salivary cytokines as biomarkers of oral cancer: a systematic review and meta-analysis

Cytokine Author Year Groups Sample (n) Mean ± SD (pg/ml) Statistic test P Value AUC
IL-1β ELASHOFF, D. et al. 2012 Oral Cancer – cohort 5 31 293 ± 396 Mann–Whitney U test and area under the curve (AUC) < 0.05 0.570
Control - cohort 5 70 169 ± 202
ARELLANO-GARCIA, M.E. et al. 2008 Oral Cancer 40 591.5 ± 618.7 Student t-test, Pearson correlation coefficient; ROC curve and area under curv With single-plex: 0.03
With multiplex: 0.04
0.840
(sensitivity = 63.9%; specificity = 100%)
Control Oral Cancer 42 79.6 ± 578
KATAKURA A. et al. 2007 Oral Cancer 19 158.9 Two-tailed t-tests < 0.05
Control 20 14.1
GLEBER-NETTO, FO. et al. 2016 Oral Cancer 60 101.0 ± 113.0 ANOVA (Kruskal - Wallis Test); Wilcoxon Two - Sample test Oral Cancer x Control = p < 0.01;
Oral Cancer x Maligmant Potencial = p < 0.004
OPMD vs. Controls = 0.542
OSCC vs. Controls = 0.721
OSCC vs. OPMD = 0.569
Malignant potentialy injuries 60 39.7 ± 28.0
Control 60 48.1 ± 42.0
LEE, L.T. et al. 2018 Oral Cancer 41 391.4 ± 540.4 Kolmogorov-Smirnov and Mann-Whitney 0.002 AUC: 0.729
(Sensitivity = 60.98%;
Specificity = 79.17%;
p = 0.0004)
Control 24 132.5 ± 175.8
BRAILO, V. et al. 2012 Oral Cancer 28 906.0 ± 62.2 Smirnoff Kolmogorof and Kruskal Wallis 0.000
Leukoplakia 29 143.0 ± 54.7
Control 31 354.0 ± 61.4