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Table 3 Salivary TNFα in oral cancer

From: Salivary cytokines as biomarkers of oral cancer: a systematic review and meta-analysis

Cytokine Author Year Groups Sample (n) Mean ± SD (pg/ml) Statistic test P Value AUC
TNF – α JURETIĆ M. et al. 2013 Oral Cancer 19 0.739 ± 0.176 Kruskal-Wallis and Mann-Whitney < 0.001
Control 19 0.013 ± 0.033
Premalignant 19 0.601 ± 0.178
RHODUS, N.L. et al. 2005 a Oral Cancer 13 28.9 ± 14.6 Not described < 0.01
Premalignant 13 10.5 ± 7.4
Control 13 3.0 ± 1.0
SAHEBJAMEE, M. et al. 2008 Oral Cancer 9 35.2 ± 51.8 One Sample Kolmogorov-Smirnov test and Mann-Whitney U < 0.05
Control 9 4.1 ± 2.1
LEE, L.T. et al. 2018 Oral Cancer 41 27.7 ± 30.9 Kolmogorov-Smirnov and Mann-Whitney < 0.001 0.749 (Sensitivity: 39.02%
Specificity: 100%
p = 0.0001)
Control 24 8.6 ± 7.3
POLZ-DACEWICZ, M. et al. 2016 Oral Cancer 78 23,100.0 Pearson Chi-Square tests. Mann-Whitney and Kruksal-Wallis 0.00002
Control 40 11,300.0
BRAILO, V. et al. 2012 Oral Cancer 28 34.0 ± 21.6 Smirnoff Kolmogorof and Kruskal Wallis 0.126
Leukoplakia 29 30.1 ± 3.01
Control 31 38.0 ± 3.23
KRISHNAN, R. et al. 2014 Cancer 100 311.9 ± 95.3 Shapiro Wilk. Kruskal-Wallis e Mann-Whitney U Cancer x Premalignant = p < 0.05
Cancer x Control = p < 0.001
0.981
(95%CI: 0.968–0.995)
Leukoplakia 50 180.1 ± 52.4
Premalignant 50 166.5 ± 49.4
Control 100 4.5 ± 2.5
RHODUS, N.L. et al. 2005b Oral lichen planus 13 74.2 ± 38.3 One-way ANOVA, Student-Newman- Keuls q-test; teste-t. < 0.0001
Oral Cancer 13 103.6 ± 61.7
Control 13 3.4 ± 2.1