From: Salivary cytokines as biomarkers of oral cancer: a systematic review and meta-analysis
Cytokine | Author | Year | Groups | Sample (n) | Mean ± SD (pg/ml) | Statistic test | P Value | AUC |
---|---|---|---|---|---|---|---|---|
TNF – α | JURETIĆ M. et al. | 2013 | Oral Cancer | 19 | 0.739 ± 0.176 | Kruskal-Wallis and Mann-Whitney | < 0.001 | – |
Control | 19 | 0.013 ± 0.033 | ||||||
Premalignant | 19 | 0.601 ± 0.178 | ||||||
RHODUS, N.L. et al. | 2005 a | Oral Cancer | 13 | 28.9 ± 14.6 | Not described | < 0.01 | – | |
Premalignant | 13 | 10.5 ± 7.4 | ||||||
Control | 13 | 3.0 ± 1.0 | ||||||
SAHEBJAMEE, M. et al. | 2008 | Oral Cancer | 9 | 35.2 ± 51.8 | One Sample Kolmogorov-Smirnov test and Mann-Whitney U | < 0.05 | – | |
Control | 9 | 4.1 ± 2.1 | ||||||
LEE, L.T. et al. | 2018 | Oral Cancer | 41 | 27.7 ± 30.9 | Kolmogorov-Smirnov and Mann-Whitney | < 0.001 | 0.749 (Sensitivity: 39.02% Specificity: 100% p = 0.0001) | |
Control | 24 | 8.6 ± 7.3 | ||||||
POLZ-DACEWICZ, M. et al. | 2016 | Oral Cancer | 78 | 23,100.0 | Pearson Chi-Square tests. Mann-Whitney and Kruksal-Wallis | 0.00002 | – | |
Control | 40 | 11,300.0 | ||||||
BRAILO, V. et al. | 2012 | Oral Cancer | 28 | 34.0 ± 21.6 | Smirnoff Kolmogorof and Kruskal Wallis | 0.126 | – | |
Leukoplakia | 29 | 30.1 ± 3.01 | ||||||
Control | 31 | 38.0 ± 3.23 | ||||||
KRISHNAN, R. et al. | 2014 | Cancer | 100 | 311.9 ± 95.3 | Shapiro Wilk. Kruskal-Wallis e Mann-Whitney U | Cancer x Premalignant = p < 0.05 Cancer x Control = p < 0.001 | 0.981 (95%CI: 0.968–0.995) | |
Leukoplakia | 50 | 180.1 ± 52.4 | ||||||
Premalignant | 50 | 166.5 ± 49.4 | ||||||
Control | 100 | 4.5 ± 2.5 | ||||||
RHODUS, N.L. et al. | 2005b | Oral lichen planus | 13 | 74.2 ± 38.3 | One-way ANOVA, Student-Newman- Keuls q-test; teste-t. | < 0.0001 | – | |
Oral Cancer | 13 | 103.6 ± 61.7 | ||||||
Control | 13 | 3.4 ± 2.1 |