Table 2 Salivary interleukin 6 in oral cancer
From: Salivary cytokines as biomarkers of oral cancer: a systematic review and meta-analysis
Cytokine | Author | Year | Groups | Sample (n) | Mean ± SD (pg/ml) | Statistic test | P Value | AUC |
|---|---|---|---|---|---|---|---|---|
IL-6 | PANNEER SELVAM N. and SADAKSHARAM J. | 2015 | Oral Cancer | 25 | 132.9 ± 59.1 | ANOVA and Kruskal-Wallis | < 0.001 | – |
Control | 25 | 9.7 ± 12.8 | ||||||
Leucoplakia | 25 | 43.0 ± 52.1 | ||||||
JURETIĆ M. et al. | 2013 | Oral Cancer | 19 | 0.707 ± 0.234 | Kruskal-Wallis and Mann-Whitney | < 0.001 | – | |
Control | 19 | 0.002 ± 0.002 | ||||||
Pre-malignant | 19 | 0.431 ± 0.217 | ||||||
SAHEBJAMEE M. et al. | 2008 | Oral Cancer | 9 | 40.9 ± 79.5 | Kolmogorov-Smirnov Test and Mann-Whitney U | < 0.05 | – | |
Control | 9 | 2.5 ± 1.3 | ||||||
ZHANG S. et al. | 2017 | Oral Cancer | 40 | 4.8 ± 1.0 | Unpaired t-test | < 0.01 | – | |
Control | 20 | 1.3 ± 0.050 | ||||||
DINESHKUMAR T. et al. | 2016 | Oral Cancer | 100 | 178.0 ± 28.3 | Nonparametric Mann–Whitney U tests and ROC curve analysis | < 0.05 | 0.900 (Sensitivity = 99.0% Specificity = 96.0%) | |
Control | 100 | 10.3 ± 6.7 | ||||||
Pre-malignant | 50 | 35.3 ± 14.3 | ||||||
Condition Premalignant | 50 | 38.3 ± 12.3 | ||||||
KATAKURA A. et al. | 2007 | Oral Cancer | 19 | 86.5 | Two-tailed t-tests | < 0.05 | – | |
Control | 20 | – | ||||||
BAGAN, L. et al. | 2015 | Oral Cancer | 20 | 435.0 ± 142.1 | Kruskal–Wallistest, Mann–Whitney U test, Spearman’s rank correlation coefficient | < 0.01 | – | |
Control | 20 | 33.4 ± 38.9 | ||||||
Proliferative verrucous leukoplakia | 20 | 151.6 ± 129.3 | ||||||
SATO, J. et al. | 2010 | Oral Cancer | 29 | 20.1 ± 36.3 | Mann-Whitney U test, Wilcoxon rank sum test, Spearman correlation coeficient | < 0.003 | – | |
Control | 19 | 0.6 ± 0.8 | ||||||
KHYANI, I.A.M. et al. | 2017 | Oral Cancer | 35 | 61.2 | Pearson Chi-Square test, one-way ANOVA test, Post Hoc. Dunnet t tes | < 0.001 | – | |
Control | 35 | – | ||||||
Pre-malignant | 35 | 217.8 | ||||||
IL-6 | RHODUS, N.L. et al. | 2005 a | Oral Cancer | 13 | 88.2 ± 43.2 | Not described | < 0.001 | – |
Control | 13 | 1.4 ± 1.0 | ||||||
Pre-malignat | 13 | 70.8 ± 24.3 | ||||||
CHENG, L.Y.S. et al. | 2014 | Oral Cancer | 5 | 178.4 ± 172.3 | Kruskal-wallis test Mann-Whitney U test (post hoc) | < 0.001 | – | |
Chronic periodontitis | 21 | 5.8 ± 4.0 | ||||||
Disease active – Oral lichen planus | 15 | 20.7 ± 22.3 | ||||||
Disease inactive – Oral lichen planus | 13 | 8.1 ± 8.0 | ||||||
Control | 21 | 4.9 ± 8.8 | ||||||
LEE, L.T. et al. | 2018 | Oral Cancer | 41 | 198.3 ± 303.8 | Kolmogorov-Smirnov and Mann-Whitney | < 0.001 | 0.823 (Sensitivity: 82.9% Specificity: 70.3% p < 0.0001) | |
Control | 24 | 69.2 ± 272.0 | ||||||
BRAILO, V. et al. | 2012 | Oral Cancer | 28 | 129.0 ± 66.3 | Smirnoff Kolmogorof and Kruskal Wallis | < 0.012 | – | |
Leukoplakia | 29 | 18.0 ± 5.2 | ||||||
Control | 31 | 16.0 ± 3.9 | ||||||
RHODUS, N.L. et al. | 2005 b | Oral lichen planus | 13 | 148.1 ± 21.3 | One-way ANOVA, Student-Newman- Keuls q-test and teste-t | < 0.0001 | – | |
Oral Cancer | 13 | 198.2 ± 47.7 | ||||||
Control | 13 | 2.3 ± 0.7 |