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Table 2 Salivary interleukin 6 in oral cancer

From: Salivary cytokines as biomarkers of oral cancer: a systematic review and meta-analysis

Cytokine Author Year Groups Sample (n) Mean ± SD (pg/ml) Statistic test P Value AUC
IL-6 PANNEER SELVAM N. and SADAKSHARAM J. 2015 Oral Cancer 25 132.9 ± 59.1 ANOVA and Kruskal-Wallis < 0.001
Control 25 9.7 ± 12.8
Leucoplakia 25 43.0 ± 52.1
JURETIĆ M. et al. 2013 Oral Cancer 19 0.707 ± 0.234 Kruskal-Wallis and Mann-Whitney < 0.001
Control 19 0.002 ± 0.002
Pre-malignant 19 0.431 ± 0.217
SAHEBJAMEE M. et al. 2008 Oral Cancer 9 40.9 ± 79.5 Kolmogorov-Smirnov Test and Mann-Whitney U < 0.05
Control 9 2.5 ± 1.3
ZHANG S. et al. 2017 Oral Cancer 40 4.8 ± 1.0 Unpaired t-test < 0.01
Control 20 1.3 ± 0.050
DINESHKUMAR T. et al. 2016 Oral Cancer 100 178.0 ± 28.3 Nonparametric Mann–Whitney U tests and ROC curve analysis < 0.05 0.900
(Sensitivity = 99.0%
Specificity = 96.0%)
Control 100 10.3 ± 6.7
Pre-malignant 50 35.3 ± 14.3
Condition Premalignant 50 38.3 ± 12.3
KATAKURA A. et al. 2007 Oral Cancer 19 86.5 Two-tailed t-tests < 0.05
Control 20
BAGAN, L. et al. 2015 Oral Cancer 20 435.0 ± 142.1 Kruskal–Wallistest, Mann–Whitney U test, Spearman’s rank correlation coefficient < 0.01
Control 20 33.4 ± 38.9
Proliferative verrucous leukoplakia 20 151.6 ± 129.3
SATO, J. et al. 2010 Oral Cancer 29 20.1 ± 36.3 Mann-Whitney U test, Wilcoxon rank sum test, Spearman correlation coeficient < 0.003
Control 19 0.6 ± 0.8
KHYANI, I.A.M. et al. 2017 Oral Cancer 35 61.2 Pearson Chi-Square test, one-way ANOVA test, Post Hoc.
Dunnet t tes
< 0.001
Control 35
Pre-malignant 35 217.8
IL-6 RHODUS, N.L. et al. 2005 a Oral Cancer 13 88.2 ± 43.2 Not described < 0.001
Control 13 1.4 ± 1.0
Pre-malignat 13 70.8 ± 24.3
CHENG, L.Y.S. et al. 2014 Oral Cancer 5 178.4 ± 172.3 Kruskal-wallis test Mann-Whitney U test (post hoc) < 0.001
Chronic periodontitis 21 5.8 ± 4.0
Disease active – Oral lichen planus 15 20.7 ± 22.3
Disease inactive – Oral lichen planus 13 8.1 ± 8.0
Control 21 4.9 ± 8.8
LEE, L.T. et al. 2018 Oral Cancer 41 198.3 ± 303.8 Kolmogorov-Smirnov and Mann-Whitney < 0.001 0.823 (Sensitivity: 82.9%
Specificity: 70.3%
p < 0.0001)
Control 24 69.2 ± 272.0
BRAILO, V. et al. 2012 Oral Cancer 28 129.0 ± 66.3 Smirnoff Kolmogorof and Kruskal Wallis < 0.012
Leukoplakia 29 18.0 ± 5.2
Control 31 16.0 ± 3.9
RHODUS, N.L. et al. 2005 b Oral lichen planus 13 148.1 ± 21.3 One-way ANOVA, Student-Newman- Keuls q-test and teste-t < 0.0001
Oral Cancer 13 198.2 ± 47.7
Control 13 2.3 ± 0.7