Table 1 Salivary interleukin 8 in oral cancer
From: Salivary cytokines as biomarkers of oral cancer: a systematic review and meta-analysis
Cytokine | Author | Year | Groups | n of cases | Mean ± SD (pg/ml) | Statistic test | p Value | AUC |
|---|---|---|---|---|---|---|---|---|
IL 8 | SAHEBJAMEE M. et al. | 2008 | Oral Cancer | 9 | 1093.7 ± 1089.0 | Kolmogorov-Smirnov Test and Mann-Whitney U | < 0.05 | – |
Control | 9 | 700.7 ± 1031.5 | ||||||
ELASHOFF, D. et al. | 2012 | Oral Cancer - cohort 4 | 36 | 2563.0 ± 2179.0 | Mann–Whitney U test and area under the curve (AUC) | < 0.05 | 0.680 | |
Control - cohort 4 | 54 | 808.0 ± 1132.0 | ||||||
Oral Cancer - cohort 5 | 31 | 2140.0 ± 2282.0 | < 0.05 | |||||
Control - cohort 5 | 70 | 739.0 ± 1002.0 | ||||||
ARELLANO-GARCIA, M.E. et al. | 2008 | Oral Cancer | 40 | 3347.7 ± 2929.0 | Student t-test, Pearson correlation coefficient; ROC curve and area under curve | With single-plex: 0.02 With multiplex: 0.04 | 0.820 (Sensitivity = 87.5% Specificity = 64.3%) | |
Oral Cancer Control | 42 | 759.4 ± 563.0 | ||||||
Periodontitis | 10 | 818.8 ± 228.4 | ||||||
Periodontitis Control | 10 | 589.2 ± 370.3 | ||||||
TANN, W. et al. | 2007 | Oral cancer | 20 | 1252.0 ± 456.0 | T-test and area under curve | < 0.00001 | 0.837 | |
Control | 20 | 577.0 ± 355.0 | ||||||
KATAKURA A. et al. | 2007 | Oral Cancer | 19 | 720.0 | Two-tailed t-tests | < 0.05 | – | |
Control | 20 | 250.0 | ||||||
RAJKUMAR, K. et al. | 2014 | Oral Cancer | 100 | 1091.7 ± 167.1 | Shapiro-Wilk’s test, Kruskal-Wallis analysis, Mann-Whitney U test, Spearman rank test, Receiver operator characteristic (ROC) curve and area under curve | < 0.05 | PML x OSCC = 0.971 (95%CI = 0.953–0.990; p < 0.0001) | |
Premalignant | 100 | 650.4 ± 207.3 | ||||||
Control | 100 | 349.6 ± 115.1 | ||||||
CHENG, L.Y.S. et al. | 2014 | Oral Cancer | 5 | 1525.3 ± 1123.9 | Kruskal-wallis test Mann-Whitney U test (post hoc) | < 0.001 | – | |
Chronic periodontitis | 21 | 738.8 ± 394.0 | ||||||
Disease active – Oral lichen planus | 15 | 1328.4 ± 731.8 | ||||||
Disease inactive – Oral lichen planus | 13 | 1083.1 ± 646.2 | ||||||
Control | 21 | 890.8 ± 563.2 | ||||||
Cytokine | Author | Year | Groups | Sample (n) | Mean ± SD (pg/ml) | Statistic test | P Value | AUC |
IL 8 | PUNYANI, S.R.; SATHAWANE, R.S. | 2013 | Oral Cancer | 25 | 1718.6 ± 668.3 | Scheffe’s analy- sis and two-tailed independent samples t test. | p < 0.0001 | – |
Oral Precancer and Oral leukoplakia | 25 | 299.5 ± 158.2 | ||||||
Control | 25 | 210.1 ± 142.3 | ||||||
LEE, L.T. et al. | 2018 | Oral Cancer | 41 | 2060.3 ± 1796.5 | Kolmogorov-Smirnov and Mann-Whitney | < 0.001 | 0.783 (Sensitivity: 65.85% Specificity: 79.17% p = 0.0002) | |
Control | 24 | 907.0 ± 833.4 | ||||||
RHODUS, N.L. et al. | 2005b | Oral lichen planus | 13 | 2492.0 ± 664.7 | One-way ANOVA, Student-Newman- Keuls q-test; t-test. | < 0.001 | – | |
Oral Cancer | 13 | 4082.8 ± 752.3 | ||||||
Control | 13 | 1507.2 ± 398.5 | ||||||
MAIE, A. R. et al. | 2004 | Oral Cancer | 32 | 720.0 | t-test, receiver operating characteristic (ROC) analyses | < 0.001 | 0.978 (Sensitivity: 86% Specificity: 97%) | |
Control | 32 | 250.0 | ||||||
KHYANI, I.A.M. et al. | 2017 | Oral Cancer | 35 | 873.6 | Pearson Chi-Square test, one-way ANOVA test, Post Hoc. Dunnet t-test | < 0.001 | – | |
Control | 35 | 52.1 | ||||||
Premalignant | 35 | 305.0 | ||||||
RHODUS, N.L. et al. | 2005 a | Oral Cancer | 13 | 3154.1 ± 1023.2 | Not described | < 0.001 | – | |
Control | 13 | 1580.7 ± 789.0 | ||||||
Premalignant | 13 | 1918.2 ± 899.1 | ||||||
GLEBER-NETTO, FO. et al. | 2016 | Oral Cancer | 60 | 283.7 ± 262.3 | ANOVA (Kruskal - Wallis Test); Wilcoxon Two - Sample test | < 0.0001 | OPMD vs. Controls = 0.467 OSCC vs. Controls = 0.449 OSCC vs. OPMD = 0.518 | |
Malignant pontentialy injuries | 60 | 140.3 ± 155.1 | ||||||
Control | 60 | 127.8 ± 110.8 |