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Table 1 Salivary interleukin 8 in oral cancer

From: Salivary cytokines as biomarkers of oral cancer: a systematic review and meta-analysis

Cytokine Author Year Groups n of cases Mean ± SD (pg/ml) Statistic test p Value AUC
IL 8 SAHEBJAMEE M. et al. 2008 Oral Cancer 9 1093.7 ± 1089.0 Kolmogorov-Smirnov Test and Mann-Whitney U < 0.05
Control 9 700.7 ± 1031.5
ELASHOFF, D. et al. 2012 Oral Cancer - cohort 4 36 2563.0 ± 2179.0 Mann–Whitney U test and area under the curve (AUC) < 0.05 0.680
Control - cohort 4 54 808.0 ± 1132.0
Oral Cancer - cohort 5 31 2140.0 ± 2282.0 < 0.05
Control - cohort 5 70 739.0 ± 1002.0
ARELLANO-GARCIA, M.E. et al. 2008 Oral Cancer 40 3347.7 ± 2929.0 Student t-test, Pearson correlation coefficient; ROC curve and area under curve With single-plex: 0.02
With multiplex: 0.04
0.820
(Sensitivity = 87.5%
Specificity = 64.3%)
Oral Cancer Control 42 759.4 ± 563.0
Periodontitis 10 818.8 ± 228.4
Periodontitis Control 10 589.2 ± 370.3
TANN, W. et al. 2007 Oral cancer 20 1252.0 ± 456.0 T-test and area under curve < 0.00001 0.837
Control 20 577.0 ± 355.0
KATAKURA A. et al. 2007 Oral Cancer 19 720.0 Two-tailed t-tests < 0.05
Control 20 250.0
RAJKUMAR, K. et al. 2014 Oral Cancer 100 1091.7 ± 167.1 Shapiro-Wilk’s test, Kruskal-Wallis analysis, Mann-Whitney U test, Spearman rank test, Receiver operator characteristic (ROC) curve and area under curve < 0.05 PML x OSCC = 0.971 (95%CI = 0.953–0.990; p < 0.0001)
Premalignant 100 650.4 ± 207.3
Control 100 349.6 ± 115.1
CHENG, L.Y.S. et al. 2014 Oral Cancer 5 1525.3 ± 1123.9 Kruskal-wallis test Mann-Whitney U test (post hoc) < 0.001
Chronic periodontitis 21 738.8 ± 394.0
Disease active – Oral lichen planus 15 1328.4 ± 731.8
Disease inactive – Oral lichen planus 13 1083.1 ± 646.2
Control 21 890.8 ± 563.2
Cytokine Author Year Groups Sample (n) Mean ± SD (pg/ml) Statistic test P Value AUC
IL 8 PUNYANI, S.R.; SATHAWANE, R.S. 2013 Oral Cancer 25 1718.6 ± 668.3 Scheffe’s analy- sis and two-tailed independent samples t test. p < 0.0001
Oral Precancer and Oral leukoplakia 25 299.5 ± 158.2
Control 25 210.1 ± 142.3
LEE, L.T. et al. 2018 Oral Cancer 41 2060.3 ± 1796.5 Kolmogorov-Smirnov and Mann-Whitney < 0.001 0.783 (Sensitivity: 65.85%
Specificity: 79.17%
p = 0.0002)
Control 24 907.0 ± 833.4
RHODUS, N.L. et al. 2005b Oral lichen planus 13 2492.0 ± 664.7 One-way ANOVA, Student-Newman- Keuls q-test; t-test. < 0.001
Oral Cancer 13 4082.8 ± 752.3
Control 13 1507.2 ± 398.5
MAIE, A. R. et al. 2004 Oral Cancer 32 720.0 t-test, receiver operating characteristic (ROC) analyses < 0.001 0.978 (Sensitivity: 86%
Specificity: 97%)
Control 32 250.0
KHYANI, I.A.M. et al. 2017 Oral Cancer 35 873.6 Pearson Chi-Square test, one-way ANOVA test, Post Hoc.
Dunnet t-test
< 0.001
Control 35 52.1
Premalignant 35 305.0
RHODUS, N.L. et al. 2005 a Oral Cancer 13 3154.1 ± 1023.2 Not described < 0.001
Control 13 1580.7 ± 789.0
Premalignant 13 1918.2 ± 899.1
GLEBER-NETTO, FO. et al. 2016 Oral Cancer 60 283.7 ± 262.3 ANOVA (Kruskal - Wallis Test); Wilcoxon Two - Sample test < 0.0001 OPMD vs. Controls = 0.467
OSCC vs. Controls = 0.449
OSCC vs. OPMD = 0.518
Malignant pontentialy injuries 60 140.3 ± 155.1
Control 60 127.8 ± 110.8