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Table 1 Univariate and multivariate analysis

From: Sequential and co-occurring DNA damage response genetic mutations impact survival in stage III colorectal cancer patients receiving adjuvant oxaliplatin-based chemotherapy

Characteristic

Univariate analysis

Multivariable analysis

HR(95%CI)

P value

HR(95%CI)

P value

Age

< 65 vs > =65

1.48 (0.64–3.45)

0.361

1.3 (0.55–3.07)

0.56

Gender

Female vs Male

0.78 (0.35–1.71)

0.534

0.72 (0.31–1.66)

0.44

Site

Left vs Right

0.85 (0.29–2.49)

0.769

1.81 (0.53–6.16)

0.34

T

T1/T2 vs T3/T4

1.08 (0.37–3.16)

0.887

1.11 (0.36–3.45)

0.853

N

N0/N1 vs N2

0.68 (0.30–1.53)

0.347

0.82 (0.35–1.92)

0.649

Mismatch Repair Status

Proficient vs Deficient

–

0.997

–

–

MMR genetic variants

Mutation vs Wild

1.03 (0.39–2.7)

0.954

0.94 (0.34–2.61)

0.914

Risk group

G1 vs G2

5.80 (2.30–14.61)

0.000187

7.46 (2.48–18.56)

0.000192

  1. Abbreviations: T tumor invasion, N lymph node, MSI microsatellite instability, G1 low-risk group, G2 high-risk group, HR hazard ratio, MMR mismatch repair