Table 5 Mixed Effects Regression Models
Parameters | Model Parameters | |||||
|---|---|---|---|---|---|---|
Parameter | Estimate (C.I.) | P-Value | SD | AIC | BIC | logLik |
Additive Model | ||||||
 lme(Cancer_Rate ~ Cigarettes + Cannabis + Analgesics + Alcohol + Cocaine) | ||||||
  Cannabis | 5.34 (0.07, 10.6) | 0.0472 | 3.43138 | 3884.77 | 3912.46 | − 1936.39 |
  Analgesics | −11.02 (− 18.65, −3.39) | 0.0048 |  |  |  |  |
Interactive Model | ||||||
 lme(Cancer_Rate ~ Cigarettes * Cannabis * Analgesics * Alcohol + Cocaine) | ||||||
  Cannabis | 72.88 (49.6, 96.15) | 1.4E-09 | 3.31033 | 3781.12 | 3836.4 | − 1878.56 |
  Cigarettes | 43.36 (27.68, 59.04) | 8.2E-08 |  |  |  |  |
  Alcohol: Analgesics | 1523.99 (970.61, 2077.38) | 9.3E-08 |  |  |  |  |
  Cigarettes: Cannabis: Analgesics | 2788.19 (1676.17, 3900.2) | 1.1E-06 |  |  |  |  |
  Cannabis: Alcohol: Analgesics | − 4554.93 (− 6709.17, − 2400.69) | 3.8E-05 |  |  |  |  |
  Cigarettes: Analgesics | −539.08 (− 790.18, − 287.99) | 2.9E-05 |  |  |  |  |
  Analgesics | −87.43 (−121.63, −53.23) | 6.9E-07 |  |  |  |  |
  Alcohol | − 82.06 (− 113.58, −50.54) | 4.3E-07 |  |  |  |  |
  Cigarettes: Cannabis | −284.5 (−376.55, − 192.45) | 2.3E-09 |  |  |  |  |
Full Interactive Model | ||||||
 lme(Cancer_Rate ~ Cigarettes * Cannabis * Analgesics * Alcohol + Cocaine + 6 Races + Income) | ||||||
  White | 11.8 (8.45, 15.14) | 1.1E-11 | 3.18221 | 3715.57 | 3784.61 | − 1842.79 |
  Cannabis | 79.27 (56.77, 101.78) | 1.2E-11 |  |  |  |  |
  Asian | 2.54 (1.8, 3.27) | 2.6E-11 |  |  |  |  |
  Cigarettes: Alcohol: Analgesics | 1636.35 (1108.24, 2164.46) | 2.1E-09 |  |  |  |  |
  Cigarettes | 45.74 (30.44, 61.04) | 7.2E-09 |  |  |  |  |
  Cigarettes: Cannabis: Analgesics | 2525.7 (1488.65, 3562.75) | 2.2E-06 |  |  |  |  |
  Alcohol: Analgesics | 959.4 (425.8, 1493) | 4.5E-04 |  |  |  |  |
  Cannabis: Alcohol: Analgesics | − 4264.85 (− 6314.08, − 2215.61) | 5.1E-05 |  |  |  |  |
  Alcohol | −93.44 (− 124.44, −62.43) | 5.5E-09 |  |  |  |  |
  Cigarettes: Analgesics | −766.56 (− 1011.12, −521.99) | 1.4E-09 |  |  |  |  |
  Cigarettes: Cannabis | −290.63 (− 373.83, −207.42) | 1.7E-11 |  |  |  |  |
  Income | −9.44 (−12.02, −6.87) | 1.7E-12 |  |  |  |  |
Full Interactive Model with Cannabinoids | ||||||
 lme(Cancer_Rate ~ Cigarettes * Δ9THC * Cannabigerol * Alcohol + Analgesics + Cocaine + 6 Races + Income) | ||||||
  White | 15.39 (11.82, 18.96) | 1.8E-16 | 3.16296 | 3743.28 | 3798.56 | − 1859.64 |
  Asian | 2.46 (1.76, 3.16) | 1.2E-11 |  |  |  |  |
  Cigarettes: Cannabigerol: Alcohol | 4741.19 (3077.86, 6404.51) | 3.3E-08 |  |  |  |  |
  Cigarettes: Δ9THC | 26.57 (15.54, 37.6) | 2.8E-06 |  |  |  |  |
  Δ9THC: Alcohol | 14.95 (7.74, 22.16) | 5.4E-05 |  |  |  |  |
  Hispanic | 0.7 (0.14, 1.26) | 1.4E-02 |  |  |  |  |
  Cigarettes: Cannabigerol | − 663.69 (− 971.24, −356.13) | 2.7E-05 |  |  |  |  |
  Income | −7.76 (−10.11, −5.41) | 1.9E-10 |  |  |  |  |
  Cigarettes: Δ9THC: Alcohol | −240.65 (− 304.57, − 176.72) | 4.6E-13 |  |  |  |  |