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Table 2 Linear Models: TPCIR Against Time, Cannabis, Cannabinoids and Ethnicity

From: A geospatiotemporal and causal inference epidemiological exploration of substance and cannabinoid exposure as drivers of rising US pediatric cancer rates

Parameter Estimates

Model Parameters

Parameter

Estimate (C.I.)

Pr(>|t|)

R-Squared

F

dF

P

lm(Cancer_Rate ~ Time)

 Year

0.14 (0.1, 0.17)

3.8E-14

0.0725

59.6

1748

3.80E-14

lm(Cancer_Rate ~ Cannabis)

 mrjmon

1.00 (−1.22, 3.22)

0.3800

−0.0003

0.78

1748

0.3770

lm(Cancer_Rate ~ Δ9THC)

 Δ9THC

0.33 (0.15, 0.5)

0.0002

0.0169

13.8

1748

0.0002

lm(Cancer_Rate ~ Exposure * Drug)

 Drug_Rate: Cannabis

4.63 (2.11, 7.15)

0.0003

0.0207

9.82

93,740

5.39E-15

 Drug_Rate: Alcohol

−3.22 (−6.21, −0.22)

0.0356

    

 Drug_Rate: Analgesics

−6.63 (−10.51, −2.75)

0.0008

    

 Cocaine

−1.06 (− 1.63, −0.49)

0.0003

    

 Cannabis

−1.32 (− 1.89, −0.74)

0.0000

    

 Drug_Rate

−3.63 (−4.86, −2.4)

0.0000

    

lm(Cancer_Rate ~ Exposure * Cannabinoid)

 Cannabinol

6.54 (5.07, 8.01)

< 2E-16

0.0402

18.9

72,992

< 2E-16

 Cannabigerol

7.65 (5.91, 9.38)

< 2E-16

    

 Drug_Rate

2.14 (1.55, 2.73)

0.0000

    

 Cannabichromene

3.86 (0.29, 7.42)

0.0340

    

 Drug_Rate: Cannabichromene

−3.02 (−5.4, −0.63)

0.0130

    

lm(Cancer_Rate ~ Ethnic_THC_Exposure * Ethnicity)

 Ethnic_THC_Exposure

0.14 (0.07, 0.21)

0.0001

0.0021

2.57

64,493

0.0174

 Asian-Am_THC_Exposure

0.28 (0.02, 0.55)

0.0360

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