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Table 9 Meta-analyses of studies specific leukemia types for smoking

From: The importance of evaluating specific myeloid malignancies in epidemiological studies of environmental carcinogens

Characteristics No. of estimates Meta-RR estimate (95%CI) I2 test (%) p-value Egger’s test
ML
 Overall 6 1.54 (0.79–3.01) 81.80 0.2038 0.8539
 Smoking status
  Current smoker 3 1.55 (0.44–5.46) 75.24 0.4942 0.4930
  Ever smoker 3 1.68 (1.45–1.94) 0.00 < 0.0001 0.9406
 Study type
  Case-control studies 1 0.52 (0.31–0.88) 000 < 0.00001 NA
  Cohort studies 5 1.71 (1.49–1.98) 0.00 < 0..0001 0.5972
AML
 Overall 28 1.43 (1.25–1.62) 56.25 < 0.0001 0.0848
 Smoking status
  Current smoker 21 1.49 (1.28–1.72) 53.64 < 0.0001 0.3747
  Ever smoker 7 1.22 (1.00–1.48) 34.43 0.00497 0.1008
 Study type
  Case-control studies 23 1.43 (1.26–1.63) 46.25 < 0.0001 0.3784
  Cohort studies 5 1.43 (1.03–1.99) 69.14 0.0351 0.0882
CML
 Overall 14 0.93 (0.74–1.16) 40.44 0.5242 0.7871
 Smoking status
 Current smoker 8 0.81 (0.64–1.01) 0.00 0.0637 0.0347a
 Ever smoker 6 1.05 (0.71–1.56) 56.51 0.8101 0.6791
 Study type
  Case-control studies 11 0.88 (0.69–1.11) 25.34 0.2641 0.1266
  Cohort studies 3 1.08 (0.67–1.74) 48.86 0.7513 0.8573
MDS
 Overall 22 1.66 (1.38–2.00) 61.89 < 0.0001 0.7014
 Smoking status
  Current smoker 13 1.69 (1.28–2.22) 62.94 0.0002 0.9380
 Ever smoker 7 1.51 (1.21–1.87) 44.07 0.0002 0.1445
 Study type
  Case-control studies 18 1.42 (1.25–1.62) 2.32 < 0.0001 0.3969
  Cohort studies 4 2.58 (1.80–3.70) 63.99 < 0.0001 0.4004
MPN
 Overall 3 1.70 (1.23–2.34) 0.00 0.0013 0.9210
 Smoking status
 Current smoker 3 1.70 (1.23–2.34) 0.00 0.0013 0.9210
  Ever smoker 0     NA
 Study type
  Case-control studies 1 1.25 (0.59–2.66) 0.00 0.5623 NA
  Cohort studies 2 1.82 (1.27–2.59) 0.00 0.0011 NA
  1. astatistically significant