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Table 9 Meta-analyses of studies specific leukemia types for smoking

From: The importance of evaluating specific myeloid malignancies in epidemiological studies of environmental carcinogens

Characteristics

No. of estimates

Meta-RR estimate (95%CI)

I2 test (%)

p-value

Egger’s test

ML

 Overall

6

1.54 (0.79–3.01)

81.80

0.2038

0.8539

 Smoking status

  Current smoker

3

1.55 (0.44–5.46)

75.24

0.4942

0.4930

  Ever smoker

3

1.68 (1.45–1.94)

0.00

< 0.0001

0.9406

 Study type

  Case-control studies

1

0.52 (0.31–0.88)

000

< 0.00001

NA

  Cohort studies

5

1.71 (1.49–1.98)

0.00

< 0..0001

0.5972

AML

 Overall

28

1.43 (1.25–1.62)

56.25

< 0.0001

0.0848

 Smoking status

  Current smoker

21

1.49 (1.28–1.72)

53.64

< 0.0001

0.3747

  Ever smoker

7

1.22 (1.00–1.48)

34.43

0.00497

0.1008

 Study type

  Case-control studies

23

1.43 (1.26–1.63)

46.25

< 0.0001

0.3784

  Cohort studies

5

1.43 (1.03–1.99)

69.14

0.0351

0.0882

CML

 Overall

14

0.93 (0.74–1.16)

40.44

0.5242

0.7871

 Smoking status

 Current smoker

8

0.81 (0.64–1.01)

0.00

0.0637

0.0347a

 Ever smoker

6

1.05 (0.71–1.56)

56.51

0.8101

0.6791

 Study type

  Case-control studies

11

0.88 (0.69–1.11)

25.34

0.2641

0.1266

  Cohort studies

3

1.08 (0.67–1.74)

48.86

0.7513

0.8573

MDS

 Overall

22

1.66 (1.38–2.00)

61.89

< 0.0001

0.7014

 Smoking status

  Current smoker

13

1.69 (1.28–2.22)

62.94

0.0002

0.9380

 Ever smoker

7

1.51 (1.21–1.87)

44.07

0.0002

0.1445

 Study type

  Case-control studies

18

1.42 (1.25–1.62)

2.32

< 0.0001

0.3969

  Cohort studies

4

2.58 (1.80–3.70)

63.99

< 0.0001

0.4004

MPN

 Overall

3

1.70 (1.23–2.34)

0.00

0.0013

0.9210

 Smoking status

 Current smoker

3

1.70 (1.23–2.34)

0.00

0.0013

0.9210

  Ever smoker

0

   

NA

 Study type

  Case-control studies

1

1.25 (0.59–2.66)

0.00

0.5623

NA

  Cohort studies

2

1.82 (1.27–2.59)

0.00

0.0011

NA

  1. astatistically significant