Skip to main content

Table 8 Results of studies on tobacco smoking and specific type of myeloid malignancies

From: The importance of evaluating specific myeloid malignancies in epidemiological studies of environmental carcinogens

  Exposure MDS AML CML MPN. Myeloid l.
Point estimate 95% CI Point estimate 95% CI Point estimate 95% CI Point estimate 95% CI Point estimate 95% CI
Averginou 2017 [70] CS 0.94 0.46–1.91         
  ES 1.18 0.69–2.02         
Batty 2008 [71] CS          5.08 1.78–14.5
  10 cpd_c          0.45 0.28–0.73
  10 yr_c          1.27 0.71–2.26
Bjork 2000 [72] Recent smokers 2.0 1.3–3.1         
  > 10 cpd, > 40 yrs 3.5 1.9–6.4         
  > 40 pyrs 3.0 1.6–5.8         
Bjork 2001b [73] > 10 cpd, > 20 yrs    1.6 1.0–2.4       
Bjork 2009 [74] CS smoker 1.2 0.70–2.2 0.97 0.58–1.6       
  ≥20 yrs 1.4 0.78–2.5 1.1 0.63–1.8       
  ≥20 pyrs 1.6 0.85–3.1 1.1 0.60–2.0       
Brown 1992 [75] CS    1.7 0.9–2.9 1.3 0.5–3.6     
  > 20 cpd    1.3 0.7–2.4 2.1 0.8–5.3     
  ≥46 yrs    1.5 0.8–2.8 3.3 1.2–9.0     
Brownson 1991 [76] ≥20 cpd, males    1.2 0.7–1.9 0.8 0.4–1.6     
  ≥20 cpd, females    1.4 0.8–2.2 0.5 0.2–1.4     
Dalamaga 2002 [77] CS (non-drinker) 1.73 0.58–5.18         
Fernberg 2007 [78] CS    1.50 1.06–2.11 0.69 0.42–1.14     
  > 20 cpd    1.59 0.9–2.79       
Ido 1996 [79] ES 1.8 0.83–3.89         
Kabat 1988 [80] ES    0.83 0.61–1.14 0.60 0.36–1.0     
  ≥31 cpd    0.71 0.37–1.37       
Kabat 2013 [81] ≥ 21 cpd      1.53 1.03–2.27     
Kane 1999 [82] CS    1.4 1.1–1.8       
  40+ yrs    1.3 0.9–1.9       
Kasim 2005 [83] CS    1.4 1.1–1.8 0.7 0.4–1.1     
  > 20 pys    1.5 1.1–2.0 0.9 0.4–1.6     
Kroll 2012 [84] ≥ 15 cpd 1.98 1.67–2.35 1.08 0.80–1.46      1.69 1.46–1.96
Leal, 2014 [85] CS        1.61 1.06–2.45   
Linet 1991 [86] ES          0.8 0.3–1.8
  20+ cpd          1.3 0.5–3.8
Lv 2011 [87] CS 1.37 0.89–2.12         
  ≥20 yrs 1.22 0.91–1.63         
  ≥20 cpd 1.06 0.75–1.50         
  ≥20 pyrs 1.06 0.73–1.55         
Ma 2009; 2010 [88, 89] CS 3.17 2.02–4.98 NR NR       
  CS, > 1 ppd 4.70 2.68–8.24 2.29 1.38–3.79       
Mele 1994 [90] > 20 pys 2.4 1.0–5.8 1.7 0.9–3.0 1.0 0.5–2.1     
  CS 1.2 0.4–3.3 1.6 0.9–2.8 1.3 0.7–2.6     
Mills 1990 [91] CS          2.04 0.25–16.65
  > 25 cpd          3.55 1.14–11.07
  > 15 yrs          2.69 0.94–7.72
Musselman 2013 [92] > 20 cpd    2.06 1.29–3.28 1.58 0.84–2.98     
Nagata 1999 [93] CS 0.94 0.50–1.78         
  ≥20 cpd 0.98 0.51–1.88         
  ≥20 yrs 0.81 0.41–1.64         
Nisse 2001 [94] CS/Ex-S 3.4 1.7–7.3         
  ≥20 pyrs 2.6 1.1–6.8         
Parodi 2017 [95] CS    0.43 0.23–0.82 0.81 0.35–1.19    0.52 0.31–0.88
Pasqualetti 1997 [96] Heavy smokers 3.00 1.09–8.25 3.20 1.17–8.73    1.25 0.59–2.67   
Pedersen 2018 [97] Daily smokers        2.5 1.3–5.1   
Pekmezovic 2006 [98] > 25 yrs 1.0 0.4–2.3         
  > 20 cpd 1.3 0.4–3.6         
Pogoda 2002 [99] ES    1.2 0.9–1.6       
  > 35 yrs.a    2.9 1.1–7.2       
  > 20 cpda    3.4 1.4–8.2       
  > 40 pyrsa    2.3 0.9–5.6       
Richardson 2008 [100] CS      1.04 0.47–2.30     
  10 pys_c      1.07 0.97–1.17     
Sandler 1993 [101] ES 1.64 0.53–5.07 1.18 0.91–1.54       
  > 40 pyrs    1.42 1.00–2.07       
Severson 1990 [102] ES    2.1 1.2–3.9       
  CS    1.9 0.9–3.7       
  ≥40 pyrs    3.1 1.4–7.4       
Speer 2002 [103] CS    2.2 1.6–3.0       
Stagnaro 2001 [104] CS    0.93 0.61–1.4 0.59 0.34–1.0     
  ≥20 cpd    1.2 0.74–1.9 0.45 0.23–0.87     
  ≥37 yrs    1.2 0.72–1.9 0.56 0.30–1.1     
Strom 2005 [60] ES 1.65 1.19–2.30         
  Per py 1.01 1.005–1.02         
Strom 2012 [105] > 30 pyrs, women    1.34 0.72–2.50       
  > 30 pyrs, men    1.86 1.15–3.02       
Ugai 2017a [106] > 30 pys/CS    2.02 1.00–4.06 1.19 0.36–3.91     
Ugai 2017b [107] CS 1.62 0.80–3.27         
  > 30 pyrs 1.74 0.84–3.59         
Wakabayaski 1994 [108] ≥31 cpd    2.99 0.66–13.47       
West 1995 [109] ES 1.16 0.83–1.63         
  ≥25 cpd 1.0 (NR)         
Wong 2009 [110] > 20 cpd 0.96 0.58–1.57         
  > 20 yrs 1.33 0.99–1.77         
  > 20 pyrs 1.29 0.95–1.75         
Xu 2007 [111] CS    3.47 1.00–12.0       
  > 20 cpd    1.07 0.23–5.01       
  > 30 yrs    3.64 0.80–16.5       
  > 20 pys    1.11 0.19–6.36       
  1. a results for FAB subtype M2, 107 cases/107 controls
  2. Abbreviations: CS Current smoker; cpd Cigarettes per day; ES Ever smoked (combined current and former smokers); pys Pack-years; RR Relative risk; yrs. Years of smoking
\