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Table 8 Results of studies on tobacco smoking and specific type of myeloid malignancies

From: The importance of evaluating specific myeloid malignancies in epidemiological studies of environmental carcinogens

 

Exposure

MDS

AML

CML

MPN.

Myeloid l.

Point estimate

95% CI

Point estimate

95% CI

Point estimate

95% CI

Point estimate

95% CI

Point estimate

95% CI

Averginou 2017 [70]

CS

0.94

0.46–1.91

        
 

ES

1.18

0.69–2.02

        

Batty 2008 [71]

CS

        

5.08

1.78–14.5

 

10 cpd_c

        

0.45

0.28–0.73

 

10 yr_c

        

1.27

0.71–2.26

Bjork 2000 [72]

Recent smokers

2.0

1.3–3.1

        
 

> 10 cpd, > 40 yrs

3.5

1.9–6.4

        
 

> 40 pyrs

3.0

1.6–5.8

        

Bjork 2001b [73]

> 10 cpd, > 20 yrs

  

1.6

1.0–2.4

      

Bjork 2009 [74]

CS smoker

1.2

0.70–2.2

0.97

0.58–1.6

      
 

≥20 yrs

1.4

0.78–2.5

1.1

0.63–1.8

      
 

≥20 pyrs

1.6

0.85–3.1

1.1

0.60–2.0

      

Brown 1992 [75]

CS

  

1.7

0.9–2.9

1.3

0.5–3.6

    
 

> 20 cpd

  

1.3

0.7–2.4

2.1

0.8–5.3

    
 

≥46 yrs

  

1.5

0.8–2.8

3.3

1.2–9.0

    

Brownson 1991 [76]

≥20 cpd, males

  

1.2

0.7–1.9

0.8

0.4–1.6

    
 

≥20 cpd, females

  

1.4

0.8–2.2

0.5

0.2–1.4

    

Dalamaga 2002 [77]

CS (non-drinker)

1.73

0.58–5.18

        

Fernberg 2007 [78]

CS

  

1.50

1.06–2.11

0.69

0.42–1.14

    
 

> 20 cpd

  

1.59

0.9–2.79

      

Ido 1996 [79]

ES

1.8

0.83–3.89

        

Kabat 1988 [80]

ES

  

0.83

0.61–1.14

0.60

0.36–1.0

    
 

≥31 cpd

  

0.71

0.37–1.37

      

Kabat 2013 [81]

≥ 21 cpd

    

1.53

1.03–2.27

    

Kane 1999 [82]

CS

  

1.4

1.1–1.8

      
 

40+ yrs

  

1.3

0.9–1.9

      

Kasim 2005 [83]

CS

  

1.4

1.1–1.8

0.7

0.4–1.1

    
 

> 20 pys

  

1.5

1.1–2.0

0.9

0.4–1.6

    

Kroll 2012 [84]

≥ 15 cpd

1.98

1.67–2.35

1.08

0.80–1.46

    

1.69

1.46–1.96

Leal, 2014 [85]

CS

      

1.61

1.06–2.45

  

Linet 1991 [86]

ES

        

0.8

0.3–1.8

 

20+ cpd

        

1.3

0.5–3.8

Lv 2011 [87]

CS

1.37

0.89–2.12

        
 

≥20 yrs

1.22

0.91–1.63

        
 

≥20 cpd

1.06

0.75–1.50

        
 

≥20 pyrs

1.06

0.73–1.55

        

Ma 2009; 2010 [88, 89]

CS

3.17

2.02–4.98

NR

NR

      
 

CS, > 1 ppd

4.70

2.68–8.24

2.29

1.38–3.79

      

Mele 1994 [90]

> 20 pys

2.4

1.0–5.8

1.7

0.9–3.0

1.0

0.5–2.1

    
 

CS

1.2

0.4–3.3

1.6

0.9–2.8

1.3

0.7–2.6

    

Mills 1990 [91]

CS

        

2.04

0.25–16.65

 

> 25 cpd

        

3.55

1.14–11.07

 

> 15 yrs

        

2.69

0.94–7.72

Musselman 2013 [92]

> 20 cpd

  

2.06

1.29–3.28

1.58

0.84–2.98

    

Nagata 1999 [93]

CS

0.94

0.50–1.78

        
 

≥20 cpd

0.98

0.51–1.88

        
 

≥20 yrs

0.81

0.41–1.64

        

Nisse 2001 [94]

CS/Ex-S

3.4

1.7–7.3

        
 

≥20 pyrs

2.6

1.1–6.8

        

Parodi 2017 [95]

CS

  

0.43

0.23–0.82

0.81

0.35–1.19

  

0.52

0.31–0.88

Pasqualetti 1997 [96]

Heavy smokers

3.00

1.09–8.25

3.20

1.17–8.73

  

1.25

0.59–2.67

  

Pedersen 2018 [97]

Daily smokers

      

2.5

1.3–5.1

  

Pekmezovic 2006 [98]

> 25 yrs

1.0

0.4–2.3

        
 

> 20 cpd

1.3

0.4–3.6

        

Pogoda 2002 [99]

ES

  

1.2

0.9–1.6

      
 

> 35 yrs.a

  

2.9

1.1–7.2

      
 

> 20 cpda

  

3.4

1.4–8.2

      
 

> 40 pyrsa

  

2.3

0.9–5.6

      

Richardson 2008 [100]

CS

    

1.04

0.47–2.30

    
 

10 pys_c

    

1.07

0.97–1.17

    

Sandler 1993 [101]

ES

1.64

0.53–5.07

1.18

0.91–1.54

      
 

> 40 pyrs

  

1.42

1.00–2.07

      

Severson 1990 [102]

ES

  

2.1

1.2–3.9

      
 

CS

  

1.9

0.9–3.7

      
 

≥40 pyrs

  

3.1

1.4–7.4

      

Speer 2002 [103]

CS

  

2.2

1.6–3.0

      

Stagnaro 2001 [104]

CS

  

0.93

0.61–1.4

0.59

0.34–1.0

    
 

≥20 cpd

  

1.2

0.74–1.9

0.45

0.23–0.87

    
 

≥37 yrs

  

1.2

0.72–1.9

0.56

0.30–1.1

    

Strom 2005 [60]

ES

1.65

1.19–2.30

        
 

Per py

1.01

1.005–1.02

        

Strom 2012 [105]

> 30 pyrs, women

  

1.34

0.72–2.50

      
 

> 30 pyrs, men

  

1.86

1.15–3.02

      

Ugai 2017a [106]

> 30 pys/CS

  

2.02

1.00–4.06

1.19

0.36–3.91

    

Ugai 2017b [107]

CS

1.62

0.80–3.27

        
 

> 30 pyrs

1.74

0.84–3.59

        

Wakabayaski 1994 [108]

≥31 cpd

  

2.99

0.66–13.47

      

West 1995 [109]

ES

1.16

0.83–1.63

        
 

≥25 cpd

1.0

(NR)

        

Wong 2009 [110]

> 20 cpd

0.96

0.58–1.57

        
 

> 20 yrs

1.33

0.99–1.77

        
 

> 20 pyrs

1.29

0.95–1.75

        

Xu 2007 [111]

CS

  

3.47

1.00–12.0

      
 

> 20 cpd

  

1.07

0.23–5.01

      
 

> 30 yrs

  

3.64

0.80–16.5

      
 

> 20 pys

  

1.11

0.19–6.36

      
  1. a results for FAB subtype M2, 107 cases/107 controls
  2. Abbreviations: CS Current smoker; cpd Cigarettes per day; ES Ever smoked (combined current and former smokers); pys Pack-years; RR Relative risk; yrs. Years of smoking