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Table 4 Select characteristics of included benzene studies

From: The importance of evaluating specific myeloid malignancies in epidemiological studies of environmental carcinogens

Reference Study design Population or
Cases / controls
Study setting Years of follow-up Adjusted for smoking
Adegoke 2003 [37] Population-based case-control 236 AML cases; 79 CML cases
502 controls
China: Shanghai 1987–1989 No
Albin 2003 [38] Population-based case-control 330 MDS cases
337 controls
Southern Sweden 1976–1993 Noa
Blair 2001 [39] Population-based case-control 132 AML cases; 46 CML cases; 58 MDS cases
1087 controls
USA: Iowa and Minnesota 1976–1993 Yes
Bjork 2001a [40] Population-based case-control 226 CML cases
251 controls
Southern Sweden 1980–1984 No*
Bonzini 2019 [41] Occupational cohort 5112 oil refinery workers Italy 1976–1993 No
Collins 2015 [42] Occupational cohort 2266 chemical workers USA: Michigan 1944–1977 No
Copley 2017 [43] Hospital-based case control 604 MDS cases
1193 controls
China: Shanghai 2003–2007 Noa
Costantini 2008 [44] Population-based case-control 142 AML cases
893 controls
Italy 1991–1993 Noa
Divine 1999 [45] Occupational cohort 28,480 oil refinery and petrochemical workers USA: Texas 1947–1993 No
Divine 2000 [46] Occupational cohort 24,124 oil production and pipeline workers USA 1946–1994 No
Guenel 2002 [47] Nested case-control 26 AML cases
103 controls
France 1978–1989 No
Huebner 2009 [48] Occupational cohort 127,266 petroleum workers USA: Louisiana and Texas 1979–2000 No
Ireland 1997 [49] Occupational cohort 4172 chemical workers USA: Illinois 1940–1991 No
Kirkeleit 2008 [50] Occupational case-control 27,919 upstream petroleum workers Norway 1981–2003 No
Linet 2015 [51] Occupational cohort 73,789 benzene-exposed and 34,405 unexposed workers China 1972–1999 No
McCraw 1985 [52] Occupational cohort 3976 oil refinery workers USA: Illinois 1973–1982 No
Poynter 2017 [53] Population-based case-control 420 AML cases; 265 MDS cases
1388 controls
USA: Minnesota 2010–2014 Yes
Rhomberg 2016 [54] Occupational cohort 1696 Pliofilm workers USA: Ohio 1940–1996 No
Rushton 2014 [55] Nested case-control 60 AML cases
241 controls
Canada, UK, and Australia 1950–2006c No
Saberi Hosnijeh 2013 [33] Population-based cohort 241,465 adults (European Prospective Investigation into Cancer and Nutrition cohort) 10 European countries: Denmark, France, Greece, Germany, Italy, The Netherlands, Norway, Spain, Sweden, and the UK 1992–2010 Yes
Sathiakumar 1995 [56] Occupational case-control 10 AML cases; 5 CML cases; 42 controls USA 1976–1990 No
Satin 1996 [57] Occupational cohort 17,844 Port Arthur oil refinery workers USA: Texas 1937–1987 No
Schnatter 2012 [58] Occupational case-control 29 MDS cases; 60 AML cases; 30 MPD cases; 28 CML cases
616 controls
Canada, UK, and Australia 1950–2006c Noa
Stenehjem 2015 [59] Occupational cohort 4 MDS cases; 10 AML cases; 3 CML cases b
1661 controls
Norway 1999–2011 Yes
Strom 2005 [60] Hospital-based case-control 354 MDS cases
452 controls
USA: Texas 1999–2003 Yes
Talibov 2014 [34] Population-based case-control 14,982 AML cases
74,505 controls
4 Nordic countries: Finland, Norway, Sweden, and Iceland 1960–2005c No
Teras 2019 [61] Population-based cohort 115,996 adults (American Cancer Prevention Study-II Nutrition cohort) USA 1997–2013 Yes
Wong 1993 [62] Occupational cohort 18,135 gasoline distribution workers USA 1946–1986 No
Wong 2001a [63] Occupational cohort 7543 petroleum refinery workers USA: Texas 1945–1996 No
Wong 2001b [64] Occupational cohort 3328 petroleum refinery workers USA: California 1959–1997 No
Wong 2010 [65] Hospital-based case-control 722 AML cases
1444 controls
China: Shanghai 2003–2007 No
  1. a Statistical model was not adjusted for smoking status, however smoking status was investigated and reported independently
  2. b MDS and CML were not analyzed
  3. c Study period varies by country
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