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Table 2 Formaldehyde exposure and risk of specific types of myeloid malignancy by exposure category

From: The importance of evaluating specific myeloid malignancies in epidemiological studies of environmental carcinogens

Reference

Exposure

Category

Myeloid leukemia

AML

CML

No. of cases

Point estimate

95% CI

No. of cases

Point estimate

95% CI

No. of cases

Point estimate

95% CI

Overall Results in Most Informative Cohorts

Meyers 2013 [29]

Exposed

21

1.28

0.79–1.96

14

1.22

0.67–2.05

5

1.35

0.44–3.15

Coggon 2014 [30]

Exposed

36

1.20

0.84–1.66

      

Checkoway 2015 [31]

Exposed

44

0.86

0.64–1.16

30

0.80

0.56–1.14

13

0.97

0.56–1.67

Results of Category at Highest Exposure in Studies

Beane Freeman 2009 [32]

Peak exposure > 4 ppm

19

1.78

0.87–3.64

      

Checkoway 2015 [31]

Peak exposure > 4 ppm

10

1.80

0.85–3.79

6

1.43

0.56–3.63

4

3.07

0.83–11.40

Cumulative exposure > 2.5 ppm-yrs

14

0.94

0.47–1.86

10

0.96

0.43–2.16

4

0.92

0.25–3.36

Coggon 2014 [30]

High exposure, > one year

50

0.96

0.24–3.82

      

Saberi Hosjineh 2013 [33]

≥Low exposure

   

N/A

1.01

0.65–1.57

N/A

0.92

0.46–1.84

Meyers 2013 [29]

Duration of exposure 10 + yrs.

10

1.84

0.88–3.38

7

1.81

0.73–3.73

   

Talibov 2014 [34]

Cumulative exposure > 1.6 ppm-yrs

   

424

1.17

0.91–1.51