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Table 2 Formaldehyde exposure and risk of specific types of myeloid malignancy by exposure category

From: The importance of evaluating specific myeloid malignancies in epidemiological studies of environmental carcinogens

Reference Exposure
Category
Myeloid leukemia AML CML
No. of cases Point estimate 95% CI No. of cases Point estimate 95% CI No. of cases Point estimate 95% CI
Overall Results in Most Informative Cohorts
Meyers 2013 [29] Exposed 21 1.28 0.79–1.96 14 1.22 0.67–2.05 5 1.35 0.44–3.15
Coggon 2014 [30] Exposed 36 1.20 0.84–1.66       
Checkoway 2015 [31] Exposed 44 0.86 0.64–1.16 30 0.80 0.56–1.14 13 0.97 0.56–1.67
Results of Category at Highest Exposure in Studies
Beane Freeman 2009 [32] Peak exposure > 4 ppm 19 1.78 0.87–3.64       
Checkoway 2015 [31] Peak exposure > 4 ppm 10 1.80 0.85–3.79 6 1.43 0.56–3.63 4 3.07 0.83–11.40
Cumulative exposure > 2.5 ppm-yrs 14 0.94 0.47–1.86 10 0.96 0.43–2.16 4 0.92 0.25–3.36
Coggon 2014 [30] High exposure, > one year 50 0.96 0.24–3.82       
Saberi Hosjineh 2013 [33] ≥Low exposure     N/A 1.01 0.65–1.57 N/A 0.92 0.46–1.84
Meyers 2013 [29] Duration of exposure 10 + yrs. 10 1.84 0.88–3.38 7 1.81 0.73–3.73    
Talibov 2014 [34] Cumulative exposure > 1.6 ppm-yrs     424 1.17 0.91–1.51    
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