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Table 3 Association between the target gene mutations and several clinicopathological variables

From: Mutational profiles of marker genes of cervical carcinoma in Bangladeshi patients

For KRAS gene mutations only
Variables Cases Wild Type (n = 42) Mutant (n = 4) p-value (Fisher’s exact test)
Age (yr)
 30–45 26 25 1 0.303
  > 45 20 17 3
HPV infections
 HPV 16 21 18 3 0.672
 HPV 18 7 7 0
 HPV 16 & 18 17 16 1
 Negative 1 1 0
FIGO stage
 IA 14 11 3 0.136
 IB 20 20 0
 IIA 8 7 1
 IIB 4 4 0
For PIK3CA gene mutations only
Variables Cases Wild Type (n = 29) Mutant (n = 17) p-value (Fisher’s exact test)
Age (yr)
 30–45 26 15 11 0.538
  > 45 20 14 6
HPV infections
 HPV 16 21 15 6 0.480
 HPV 18 7 3 4
 HPV 16 & 18 17 10 7
 Negative 1 1 0
FIGO stage
 IA 14 8 6 0.788
 IB 20 13 7
 IIA 8 6 2
 IIB 4 2 2
For EGFR gene mutations only
Variables Cases Wild Type (n = 37) Mutant (n = 9) p-value (Fisher’s exact test)
Age (yr)
 30–45 26 20 6 0.711
  > 45 20 17 3
HPV infections
 HPV 16 21 17 4 0.391
 HPV 18 7 6 1
 HPV 16 & 18 17 14 3
 Negative 1 0 1
FIGO stage
 IA 14 11 3 0.291
 IB 20 14 6
 IIA 8 8 0
 IIB 4 4 0
Considering all gene mutations
Variables Cases Wild-Type (n = 20) Mutant (n = 26) p-value (Fisher’s exact test)
Age (yr)
 30–45 26 11 15 > 0.999
  > 45 20 9 11
HPV infections
 HPV 16 21 10 11 0.955
 HPV 18 7 3 4
 HPV 16 & 18 17 7 10
 Negative 1 0 1
FIGO stage
 IA 14 4 10 0.480
 IB 20 9 11
 IIA 8 5 3
 IIB 4 2 2