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Fig. 5 | BMC Cancer

Fig. 5

From: Blockage of AMPK-ULK1 pathway mediated autophagy promotes cell apoptosis to increase doxorubicin sensitivity in breast cancer (BC) cells: an in vitro study

Fig. 5

Inhibition of AMPK-ULK1 pathway aggravated the promoting effects of high-dose doxorubicin-induced cell death in DR-BC cells. a, b CCK-8 assay results indicated that blockage of AMPK-ULK1 pathway by compound C and SBI-0206965 inhibited cell proliferation in DR-BC cells treated with high-dose doxorubicin. c Trypan blue staining assay was used to detect cell viability. d, e Cell apoptosis ratio was measured by using the Annexin V-FITC/PI double staining assay. Each experiment repeated at least 3 times, and *P < 0.05 was regarded as statistical significance

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