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Fig. 6 | BMC Cancer

Fig. 6

From: Super-enhancer-associated long noncoding RNA AC005592.2 promotes tumor progression by regulating OLFM4 in colorectal cancer

Fig. 6

AC005592.2 directly regulates OLFM4 expression in CRC cells. a Four candidate genes (MLEC, DSCAML1, OLFM4, HAS1) were obtained in the study. I: 579 dysregulated genes obtained from the RNA-seq assay; II: 165 differentially expressed mRNAs identified from the SE-lncRNA microarray. III: 4 candidate genes (MLEC, DSCAML1, OLFM4, HAS1). b Four candidate genes were confirmed by qRT-PCR in the AC005592.2 knockdown HCT-116 and HT-29 cells. c Four candidate genes were confirmed by qRT-PCR in the AC005592.2-overexpressing HCT-116 and HT-29 cells. d OLMF4 protein levels in the AC005592.2 knockdown HCT-116 and HT-29 cells. e OLMF4 expression in CRC tissues was significantly higher than that in peritumoral tissues. * P < 0.05, ** P < 0.01

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