Fig. 3

Common mutation pattern in double cancer, metastatic cancer, and multifocal lesions derived from identical tissues. a Frequency of matched and mismatched mutation positions in paired samples. b Concordance rate of nonsynonymous and synonymous mutations in each sample. c Comparison of tumor mutational burden (TMB) between tumors with or without matched mutations. The asterisk represents significant differences corrected with Bonferroni’s method (p < 0.01/3)