Fig. 2
From: Mutational concordance analysis provides supportive information for double cancer diagnosis
Comparison of mutation frequency in tumors derived from the same patient. a Transition of tumor mutational burden (TMB) in double/multifocal cancer and metastatic cancer. Primary 1 and 2 in double/multifocal cancer were determined in the first and second operation, respectively. Samples with decreased and increased TMB during primary 2 and metastasis are represented on the upper and lower panels, respectively. b Variation of TMB in the three cancer types. This rate represents an increase of TMB in primary 2 or metastasis when it exceeds 1.0