Table 2 The cumulative incidence rates of early transplant-related mortality after allogeneic hematopoietic cell transplantation
Variables | Total | Number of early TRM (%) | |||
|---|---|---|---|---|---|
Within 50 days | p-value | Within 100 days | p-value | ||
Total | 5395 | 151 (2.9) | 442 (8.3) | ||
Year of transplantation | |||||
2003–2009 | 1958 | 47 (2.4) | 0.210 | 160 (8.2) | 1.000 |
2010–2015 | 3437 | 104 (3.0) | 282 (8.2) | ||
Recipient age, years | |||||
Mean | 35.9 ± 16.6 | 39.1 ± 16.3 | 0.017 | 38.0 ± 16.9 | 0.005 |
0–19 | 1145 | 22 (1.9) | 0.164 | 76 (6.6) | 0.015 |
20–39 | 1707 | 47 (2.8) | 127 (7.4) | ||
40–59 | 2229 | 73 (3.3) | 213 (9.6) | ||
≥ 60 | 314 | 9 (2.9) | 26 (8.3) | ||
Recipient sex | |||||
Male | 2973 | 69 (2.3) | 0.023 | 239 (8.0) | 0.685 |
Female | 2422 | 82 (3.4) | 203 (8.4) | ||
Diagnosis | |||||
ALL | 1905 | 65 (3.4) | 0.054 | 179 (9.4) | 0.020 |
AML | 3490 | 86 (2.5) | 263 (7.5) | ||
Time from diagnosis to transplantation, months | |||||
< 9 | 4434 | 93 (2.1) | < 0.001 | 315 (7.1) | < 0.001 |
≥ 9 | 961 | 58 (6.0) | 127 (13.2) | ||
Previous transplantations | |||||
No | 5064 | 120 (2.4) | < 0.001 | 385 (7.6) | < 0.001 |
Yes | 331 | 31 (9.4) | 57 (17.2) | ||
Previous iron chelation therapy | |||||
No | 4602 | 149 (3.2) | < 0.001 | 428 (9.3) | < 0.001 |
Yes | 793 | 2 (0.3) | 14 (1.8) | ||
Graft source | |||||
Peripheral blood | 4041 | 119 (2.9) | < 0.001 | 333 (8.2) | < 0.001 |
Bone marrow | 1141 | 19 (1.7) | 70 (6.1) | ||
Cord blood | 213 | 13 (6.1) | 39 (18.3) | ||
Use of ATG | |||||
No | 3061 | 77 (2.5) | 0.173 | 229 (7.5) | 0.033 |
Yes | 2334 | 74 (3.2) | 213 (9.1) | ||