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Table 2 The cumulative incidence rates of early transplant-related mortality after allogeneic hematopoietic cell transplantation

From: Early transplantation-related mortality after allogeneic hematopoietic cell transplantation in patients with acute leukemia

Variables Total Number of early TRM (%)
Within 50 days p-value Within 100 days p-value
Total 5395 151 (2.9)   442 (8.3)  
Year of transplantation
 2003–2009 1958 47 (2.4) 0.210 160 (8.2) 1.000
 2010–2015 3437 104 (3.0)   282 (8.2)  
Recipient age, years
 Mean 35.9 ± 16.6 39.1 ± 16.3 0.017 38.0 ± 16.9 0.005
 0–19 1145 22 (1.9) 0.164 76 (6.6) 0.015
 20–39 1707 47 (2.8)   127 (7.4)  
 40–59 2229 73 (3.3)   213 (9.6)  
  ≥ 60 314 9 (2.9)   26 (8.3)  
Recipient sex
 Male 2973 69 (2.3) 0.023 239 (8.0) 0.685
 Female 2422 82 (3.4)   203 (8.4)  
Diagnosis
 ALL 1905 65 (3.4) 0.054 179 (9.4) 0.020
 AML 3490 86 (2.5)   263 (7.5)  
Time from diagnosis to transplantation, months
  < 9 4434 93 (2.1) < 0.001 315 (7.1) < 0.001
  ≥ 9 961 58 (6.0)   127 (13.2)  
Previous transplantations
 No 5064 120 (2.4) < 0.001 385 (7.6) < 0.001
 Yes 331 31 (9.4)   57 (17.2)  
Previous iron chelation therapy
 No 4602 149 (3.2) < 0.001 428 (9.3) < 0.001
 Yes 793 2 (0.3)   14 (1.8)  
Graft source
 Peripheral blood 4041 119 (2.9) < 0.001 333 (8.2) < 0.001
 Bone marrow 1141 19 (1.7)   70 (6.1)  
 Cord blood 213 13 (6.1)   39 (18.3)  
Use of ATG
 No 3061 77 (2.5) 0.173 229 (7.5) 0.033
 Yes 2334 74 (3.2)   213 (9.1)  
  1. TRM Transplant-related mortality; ALL Acute lymphocytic leukemia; AML Acute myeloid leukemia; ATG Antithymocyte globulin
  2. Values are presented as means ± standard deviations or numbers of cases (%)