Table 1 Characteristics of patients who underwent allogeneic hematopoietic cell transplantation by time period (N = 5395)
Characteristics | Total (%) | 2003–2009 (%) | 2010–2015 (%) | p-value |
|---|---|---|---|---|
Number | 5395 | 1958 | 3437 | |
Recipient age, years | ||||
Mean | 35.9 ± 16.6 | 31.8 ± 16.2 | 38.3 ± 16.3 | < 0.001 |
0–19 | 1145 (21.2) | 532 (27.2) | 613 (17.8) | < 0.001 |
20–39 | 1707 (31.7) | 700 (35.7) | 1007 (29.3) | |
40–59 | 2229 (41.3) | 679 (34.7) | 1550 (45.1) | |
≥ 60 | 314 (5.8) | 47 (2.4) | 267 (7.8) | |
Recipient sex | ||||
Male | 2973 (55.1) | 1074 (54.9) | 1899 (55.3) | 0.798 |
Female | 2422 (44.9) | 884 (45.1) | 1538 (44.7) | |
Diagnosis | ||||
ALL | 1905 (35.3) | 673 (34.4) | 1232 (35.8) | 0.290 |
AML | 3490 (64.7) | 1285 (65.6) | 2205 (64.2) | |
Time from diagnosis to transplantation, months | 8.8 ± 12.1 | 7.7 ± 8.2 | 9.5 ± 13.7 | < 0.001 |
Previous transplantation (≥1) | 331 (6.1) | 87 (4.4) | 244 (7.1) | < 0.001 |
RBC transfusion before HCT (≥3) | 2324 (43.1) | 889 (45.4) | 1435 (41.8) | 0.010 |
PLT transfusion before HCT (≥4) | 2322 (43.0) | 882 (45.0) | 1440 (41.9) | 0.027 |
Previous iron chelation therapy | 793 (14.7) | 102 (5.2) | 691 (20.1) | < 0.001 |
Graft source | ||||
Peripheral blood | 4041 (74.9) | 1093 (55.8) | 2948 (85.8) | < 0.001 |
Bone marrow | 1141 (21.1) | 764 (39.0) | 377 (11.0) | |
Cord blood | 213 (3.9) | 101 (5.2) | 112 (3.3) | |
Conditioning intensity | ||||
MAC | 3453 (64.0) | 1459 (74.5) | 1994 (58.0) | < 0.001 |
RIC | 1942 (36.0) | 499 (25.5) | 1443 (42.0) | |
Conditioning regimen | ||||
TBI-based | 1754 (32.5) | 629 (32.1) | 1125 (32.7) | < 0.001 |
Busulfan-based | 3272 (60.6) | 1136 (58.0) | 2136 (62.1) | |
Non-TBI, Non-busulfan | 369 (6.8) | 193 (9.9) | 176 (5.1) | |
Use of ATG | ||||
No | 3061 (56.7) | 1593 (81.4) | 1468 (42.7) | < 0.001 |
Yes | 2334 (43.3) | 365 (18.6) | 1969 (57.3) | |