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Table 2 Univariate and multivariate Cox regression analysis of Overall survival (ICC Training Cohort)

From: Clinical characteristics and overall survival prognostic nomogram for invasive cribriform carcinoma of breast: a SEER population-based analysis

Characteristics

Univariate analysis

Multivariate analysis

HR(95%CI)

P-value

HR(95%CI)

P-value

Age

 

< 0.001

 

< 0.001

 < 68

Reference

 

Reference

 

 68–78

2.025 (1.071–3.827)

0.030

2.576 (1.262–5.258)

0.009

 79+

8.326 (4.848–14.299)

< 0.001

14.362 (7.309–28.222)

< 0.001

Race

 

0.228

  

 White

Reference

   

 Black

1.508 (0.746–3.051)

0.253

  

 Other

0.546 (0.198–1.506)

0.242

  

Sex

 

0.355

  

 Female

Reference

   

 Male

1.944 (0.476–7.945)

0.355

  

Marital

 

0.003

 

< 0.001

 Married

Reference

 

Reference

 

 Single

2.343 (1.251–4.389)

0.008

4.087 (2.019–8.275)

< 0.001

 Divorced

2.371 (1.382–4.068)

0.002

1.66 (0.888–3.105)

0.113

Site

 

0.038

 

0.022

 Other

Reference

 

Reference

 

 502

0.392 (0.165–0.929)

0.033

0.485 (0.201–1.171)

0.108

 503

0.206 (0.028–1.504)

0.119

0.217 (0.025–1.87)

0.164

 504

0.525 (0.307–0.897)

0.018

0.45 (0.25–0.813)

0.008

 505

0.55 (0.196–1.545)

0.257

0.309 (0.102–0.941)

0.039

Laterality

 

0.317

  

 Left

Reference

   

 Right

0.782 (0.484–1.266)

0.317

  

Grade

    

 I + II

Reference

   

 II + IV

1.057 (0.425–2.628)

0.904

  

AJCC stage

 

< 0.001

  

 I

Reference

   

 II

1.413 (0.829–2.409)

0.204

  

 III

1.901 (0.678–5.335)

0.222

  

 IV

32.616 (13.295–80.013)

< 0.001

  

T stage

 

< 0.001

 

< 0.001

 T1

Reference

 

Reference

 

 T2

1.777 (1.026–3.079)

0.040

1.656 (0.887–3.094)

0.113

 T3

1.711 (0.531–5.516)

0.368

2.175 (0.651–7.266)

0.207

 T4

12.661 (4.522–35.453)

0.000

40.392 (9.908–164.669)

< 0.001

N stage

 

0.070

  

 N0

Reference

   

 N1

1.034 (0.527–2.029)

0.922

  

 N2

0.768 (0.106–5.55)

0.793

  

 N3

4.78 (1.49–15.333)

0.009

  

M stage

 

< 0.001

 

< 0.001

 M0

Reference

 

Reference

 

 M1

28.362 (11.839–67.949)

< 0.001

52.29 (13.76–198.705)

< 0.001

ER status

 

0.749

  

 Negative

Reference

   

 Positive

1.208 (0.379–3.847)

0.749

  

PR status

 

0.001

 

0.001

 Negative

Reference

 

Reference

 

 Positive

0.408 (0.236–0.706)

0.001

0.363 (0.199–0.662)

0.001

HER-2 status

 

0.199

  

 Negative

Reference

   

 Positive

2.273 (0.677–7.629)

0.184

  

 Unknown

0.781 (0.436–1.398)

0.405

  

Surgery

 

< 0.001

 

0.019

 No

Reference

 

Reference

 

 Yes

0.127 (0.058–0.278)

< 0.001

0.27 (0.09–0.809)

0.019

Radiaotherapy

 

< 0.001

  

 No

Reference

   

 Yes

0.343 (0.205–0.574)

< 0.001

  

Chemotherapy

 

0.009

  

 No

Reference

   

 Yes

0.353 (0.161–0.771)

0.009

  
  1. Abbreviations: ICC Invasive cribriform carcinoma, IDC Infiltrating ductal carcinoma, 502 Upper-inner quadrant of breast, 503 Lower-inner quadrant of breast, 504 Upper-outer quadrant of breast, 505 Lower-outer quadrant of breast, ER Estrogen receptor, PR Progesterone receptor, HER-2 Human epidermal growth factor receptor 2
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