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Table 2 Univariate and multivariate Cox regression analysis of Overall survival (ICC Training Cohort)

From: Clinical characteristics and overall survival prognostic nomogram for invasive cribriform carcinoma of breast: a SEER population-based analysis

Characteristics Univariate analysis Multivariate analysis
HR(95%CI) P-value HR(95%CI) P-value
Age   < 0.001   < 0.001
 < 68 Reference   Reference  
 68–78 2.025 (1.071–3.827) 0.030 2.576 (1.262–5.258) 0.009
 79+ 8.326 (4.848–14.299) < 0.001 14.362 (7.309–28.222) < 0.001
Race   0.228   
 White Reference    
 Black 1.508 (0.746–3.051) 0.253   
 Other 0.546 (0.198–1.506) 0.242   
Sex   0.355   
 Female Reference    
 Male 1.944 (0.476–7.945) 0.355   
Marital   0.003   < 0.001
 Married Reference   Reference  
 Single 2.343 (1.251–4.389) 0.008 4.087 (2.019–8.275) < 0.001
 Divorced 2.371 (1.382–4.068) 0.002 1.66 (0.888–3.105) 0.113
Site   0.038   0.022
 Other Reference   Reference  
 502 0.392 (0.165–0.929) 0.033 0.485 (0.201–1.171) 0.108
 503 0.206 (0.028–1.504) 0.119 0.217 (0.025–1.87) 0.164
 504 0.525 (0.307–0.897) 0.018 0.45 (0.25–0.813) 0.008
 505 0.55 (0.196–1.545) 0.257 0.309 (0.102–0.941) 0.039
Laterality   0.317   
 Left Reference    
 Right 0.782 (0.484–1.266) 0.317   
Grade     
 I + II Reference    
 II + IV 1.057 (0.425–2.628) 0.904   
AJCC stage   < 0.001   
 I Reference    
 II 1.413 (0.829–2.409) 0.204   
 III 1.901 (0.678–5.335) 0.222   
 IV 32.616 (13.295–80.013) < 0.001   
T stage   < 0.001   < 0.001
 T1 Reference   Reference  
 T2 1.777 (1.026–3.079) 0.040 1.656 (0.887–3.094) 0.113
 T3 1.711 (0.531–5.516) 0.368 2.175 (0.651–7.266) 0.207
 T4 12.661 (4.522–35.453) 0.000 40.392 (9.908–164.669) < 0.001
N stage   0.070   
 N0 Reference    
 N1 1.034 (0.527–2.029) 0.922   
 N2 0.768 (0.106–5.55) 0.793   
 N3 4.78 (1.49–15.333) 0.009   
M stage   < 0.001   < 0.001
 M0 Reference   Reference  
 M1 28.362 (11.839–67.949) < 0.001 52.29 (13.76–198.705) < 0.001
ER status   0.749   
 Negative Reference    
 Positive 1.208 (0.379–3.847) 0.749   
PR status   0.001   0.001
 Negative Reference   Reference  
 Positive 0.408 (0.236–0.706) 0.001 0.363 (0.199–0.662) 0.001
HER-2 status   0.199   
 Negative Reference    
 Positive 2.273 (0.677–7.629) 0.184   
 Unknown 0.781 (0.436–1.398) 0.405   
Surgery   < 0.001   0.019
 No Reference   Reference  
 Yes 0.127 (0.058–0.278) < 0.001 0.27 (0.09–0.809) 0.019
Radiaotherapy   < 0.001   
 No Reference    
 Yes 0.343 (0.205–0.574) < 0.001   
Chemotherapy   0.009   
 No Reference    
 Yes 0.353 (0.161–0.771) 0.009   
  1. Abbreviations: ICC Invasive cribriform carcinoma, IDC Infiltrating ductal carcinoma, 502 Upper-inner quadrant of breast, 503 Lower-inner quadrant of breast, 504 Upper-outer quadrant of breast, 505 Lower-outer quadrant of breast, ER Estrogen receptor, PR Progesterone receptor, HER-2 Human epidermal growth factor receptor 2