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Table 3 Multivariate Cox analysis of prognostic factors for OS, PFS, DFS. (OS: p = 0·0006, χ2 = 27·27; PFS: p = 0·065, χ2 = 19·35; DFS: p = 0·087, χ2 = 9·62)

From: Neoadjuvant chemoradiotherapy for patients with unresectable radically locally advanced colon cancer: a potential improvement to overall survival and decrease to multivisceral resection

  OS PFS DFS
HR (95%CI) p HR (95%CI) p HR (95%CI) p
KPS (80a vs 90) ·· ·· 0.50 (0.20–1.22) 0.13 0.53 (0.21–1.36) 0.2
Complication (yesa vs no) 1.70 (0.54–5.41) 0.37 1·56 (0·67–3·64) 0.3 ·· ··
Differentiation ·· 0 ·· 0.06 ·· 0.6
Higha 1 ·· 1 ·· 1 ··
Middle 3.07 (0.29–32.59) 0.35 1.60 (0.31–8.18) 0.57 1.48 (0.32–6.82) 0.6
Low 26.87 (2.38–303.60) 0.01 4.75 (0.73–22.74) 0.07 2.39 (0.42–13.51) 0.3
ypN stage (N0a vs N1 + N2) 0.31 (0.029–3.19) 0.32 0.41 (0.073–2.24) 0.3 ·· ··
ypTNM stage (0-IIBa vs IIC-IIIC) 3.44 (0.82–14.38) 0.09 1.82 (0.67–4.99) 0.24 1.49 (0.53–4.16) 0.5
pCR (yesa vs non) 0.40 (0.053–2.99) 0.37 1.18 (0.29–4.84) 0.81 ·· ··
MVR (nona vs yes) 1.07 (0.28–4.14) 0.92 0.97 (0.40–2.36) 0.95 ·· ··
VLPNI (negativea vs positive) 3.61 (0.84–15.54) 0.09 2.16 (0.77–6.02) 0.14 2.01 (0.64–6.37) 0.2
R0 resection (non-R0a vs R0) 0.21 (0.030–1.48) 0.12 0.60 (0.12–3.08) 0.54 ·· ··
  1. Abbreviations: KPS Karnofsky Performance Status, cT stage Clinical T stage, MVR Multivisceral resection, pCR Pathologic complete remission, VLPNI Vascular or lymphatic or perineural invasion
  2. aThe control group of multivariate Cox analysis