Table 2 Statistical relationships between TPX2 nuclear expression and age, tumor grade, clinical stage, tumor histology, receptor status, and presence or absence of lymph node metastases at the time of diagnosis. Percentages are rounded to the nearest whole number and may not sum to 100%

Parameters

Low

(n = 150)

n (%)

Intermediate

(n = 34)

n (%)

High

(n = 69)

n (%)

χ2 (P-value)

  ≤ 50 years

59 (39)

12 (35)

31 (45)

1.0 (0.599)

  > 50 years

91 (61)

22 (65)

38 (55)

75.6 (< 0.0001)

 1

47 (32)

2 (6)

3 (4)

 2

77 (52)

16 (48)

14 (21)

 3

25 (17)

15 (45)

51 (75)

23.5 (< 0.0001)

 1

79 (53)

9 (27)

14 (20)

 2

56 (37)

20 (61)

44 (64)

 3

15 (10)

4 (12)

11 (16)

2.9 (0.579)

 Ductal

119 (79)

26 (76)

59 (86)

 Lobular

13 (9)

2 (6)

5 (7)

 Other

18 (12)

6 (18)

5 (7)

 ER+

141 (95)

24 (73)

33 (49)

59.5 (< 0.0001)

 ER-

8 (5)

9 (27)

34 (51)

 PR+

122 (82)

20 (61)

35 (52)

22.7 (< 0.0001)

 PR-

26 (18)

13 (39)

32 (48)

 HER2+

17 (16)

6 (22)

9 (19)

0.7 (0.689)

 HER2-

92 (84)

21 (78)

39 (81)

 Positive

56 (37)

15 (44)

32 (46)

1.8 (0.409)

 Negative

94 (63)

19 (56)

37 (54)