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Table 2 Univariate and multivariate Cox regressions for candidate biomarkers in mantle cell lymphoma survival

From: Single nucleotide variants in immune-response genes and the tumor microenvironment composition predict progression of mantle cell lymphoma

Biomarker Univariate Multivariate
EFS
HR (95% CI)
p OS
HR (95% CI)
p EFS*
HR (95% CI)
p OS*
HR (95% CI)
p
Immunohistochemical model
FOXP3/CD3 ratio
  High 3.16 (1.52–6.58) 0.002 1.77 (0.75–4.19) 0.18 5.03 (1.97–12.84) 0.001a N/A N/A
  Low Reference   Reference   Reference   Reference  
CD8/CD3 ratio
  High 2.22 (1.04–4.77) 0.03 1.06 (0.44–2.51) 0.88 1.02 (0.33–3.13) 0.96 N/A N/A
  Low Reference   Reference   Reference   Reference  
Granzyme B
  High 0.50 (0.24–1.04) 0.06 0.69 (0.28–1.67) 0.41 1.18 (0.51–2.72) 0.69 N/A N/A
  Low Reference   Reference   Reference   Reference  
IL2
  High Reference 0.01 Reference   Reference 0.03b Reference 0.07
  Low 2.71 (1.26–5.83) 2.06 (0.88–4.80) 0.09 2.83 (1.06–7.58) 2.50 (0.92–6.77)
IL17A
  High 1.48 (0.73–2.97) 0.27 2.55 (1.06–6.12) 0.03 N/A N/A 4.68 (1.72–12.77) 0.003c
  Low Reference   Reference   Reference   Reference  
SNV model
IL2 rs2069762
  GG 4.26 (1.56–11.60) 0.005 9.05 (2.33–35.05) 0.001 3.13 (1.12–8.69) 0.02d 2.73 (0.86–8.67) 0.08
  GT+TT Reference   Reference   Reference   Reference  
TGFB1 rs6957
  GG 1.86 (0.43–7.92) 0.39 5.38 (1.17–24.73) 0.03 N/A N/A 3.22 (0.57–18.15) 0.18
  GA + AA Reference   Reference   Reference   Reference  
TGFBR2 rs3087465
  AA+AG 3.40 (1.60–7.22) 0.001 1.37 (0.56–3.36) 0.47 4.32 (1.88–9.93) 0.001e N/A N/A
  GG Reference   Reference   Reference   Reference  
IL10 CC haplotype
  Present 0.45 (0.21–0.97) 0.04 0.28 (0.11–0.70) 0.007 0.32 (0.14–0.74) 0.008f 0.26 (0.10–0.68) 0.006g
  Absent Reference   Reference   Reference   Reference  
IL17F rs763780
  TC + CC 0.40 (0.17–0.91) 0.03 1.16 (0.34–3.99) 0.80 1.42 (0.47–4.23) 0.52 N/A N/A
  TT Reference   Reference   Reference   Reference  
Principal components model
 Component 3 0.670 (0.40–1.10) 0.12 0.58 (0.31–1.08) 0.08 N/A N/A 0.77 (0.48–1.24) 0.29
 Component 4 1.34 (0.89–2.01) 0.15 1.65 (1.04–2.61) 0.03 N/A N/A 1.68 (1.08–2.62) 0.02h
  1. EFS Event-free survival; OS Overall survival; HR Hazard ratio; 95% CI 95% Confidence interval; SNV Single nucleotide variant; N/A Not applicable. Component 3: encompasses high levels of NK cells (CD57+), low levels of IL17A and low Ki-67. Component 4: encompasses high Ki-67 index and high counts of CD68+ and CD163+ macrophages. (*) Adjustement for B-symptoms and the MIPI index (EFS); adjustement for B-symptoms and bone marrow infiltration (OS).ap (bootstrap) = 0.02, bp (bootstrap) = 0.12, cp (bootstrap) = 0.004, dp (bootstrap) = 0.12, ep (bootstrap) = 0.004, fp (bootstrap) = 0.03, gp (bootstrap) = 0.11, hp (bootstrap) = 0.04