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Table 5 Adverse events reported with bevacizumab treatment

From: Bevacizumab for radiation necrosis following radiotherapy of brain metastatic disease: a systematic review & meta-analysis

Studies

Patients

Symptoms

Sadraei, et al. (2015) [54]

5 (29%)

Grade 1: proteinuria (1).

Grade 2: hypertension (1), fatigue (1), urinary tract infection (1).

Grade 3: DVT/pulmonary embolism (1)

Zhuang, et al. (2015) [55]

2 (14%)

Grade 1: mild allergy (1), hypertension (1)

Zhuang, et al. (2019) [33]

2 (9.5%)

Grade 1: mild allergy (1), hypertension (1)

Tanigawa, et al. (2019) [56]

4(100%)

Hypertension (3), proteinuria (3), edema (1)

Glitza, I. et al. (2017) [58]

1(14%)

Arthralgia (1), dysgeusia (1)