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Table 4 Radiographic responses and MRI changes after treatment with bevacizumab

From: Bevacizumab for radiation necrosis following radiotherapy of brain metastatic disease: a systematic review & meta-analysis

Studies No of patients Radiographic responses T1 Gd enhancement volume reduction (mean) T2 FLAIR volume reduction (mean)
Wang, et al. (2012) [50] 5 4 (80%) 63.5% 49%
Furuse, et al. (2013) [52] 3 100%   75.1%
Boothe, et al. (2013) [51] 11 100% 67.1% 54.1%
Alessandretti, et al. (2013) [48] 2 100%   
Yonezawa, et al. (2014) [53] 2 100% 49.5% 76.9%
Xiang-Pan, et al. (2015) [49] 1 100%   
Sadraei, et al. (2015) [54] 17 16 (95.8%) 52% 53.7%
Zhuang, et al. (2015) [55] 14 13 (92.9%) 36% 59%
Ma, Y., et al. (2017) [57] 2 100%   
Glitza, I. et al. (2017) [58] 7 5 (71%)   
Zhuang, et al. (2019) [33] 21 20 (95.2%) 35% 74%
Tanigawa, et al. (2019) [56] 4 100%   
This study 89 83 (93%) Mean: 47.03% (+/− 24.4) Mean: 61.78% (+/− 23.2)