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Table 1 General characteristics of the included studies

From: Bevacizumab for radiation necrosis following radiotherapy of brain metastatic disease: a systematic review & meta-analysis

Study Study design & period Location No Age M F Primary pathology Radiation RN Diagnosis RT to RN Diagnosis RT to BV Tx BV dosage No. of cycles Follow Up
Wang, et al. (2012) [50] Retrospective
Mar 2010 - Jan 2012
Huashan Hospital, Fudan University, Shanghai, China 5 65 4 1 Colon 3
Lung 2
EBRT/SRS/FSRT MRI, MRS, PET   4.6 7.5 mg/kg q2 week 2–6 6
Boothe, et al. (2013) [51] Retrospective
3-year
Memorial Sloan- Kettering Cancer Center, New York, USA 11 58 4 7 Breast 5
NSCLC 6
WBRT/SRS MRI, biopsy, PET 12.4 59.6 days 7.5 mg/kg q3w (1)
10 mg/kg q2w (8)
15 mg/kg q4/6w (2)
6 3.3
Furuse, et al. (2013) [52] Retrospective
Jan 2009 - Oct 2010
Osaka Medical College, Takatsuki, Osaka, Japan 3 62 1 2 Unknown SRS MRI, MET-PET   11 (median) 5 mg/kg q2w 3 14.4
Yonezawa, et al. (2014) [53] Prospective Nonrandomized
Jun 2010 - Sep 2011
Kizawa Memorial Hospital, Minokamo, Japan 2 52.5 1 1 Lung WBRT/SRS/SRT MRI, MET-PET 19   5 mg/kg q2w 6  
Sadraei, et al. (2015) [54] Retrospective Jul 2007 - Jun 2012 Cleveland Clinic, Cleveland, Ohio, USA 17 55.7 5 12 lung (9), breast (4), rectal (1), melanoma (1), NSTC (1), FT (1)), WBRT/SRS MRI, PET, biopsy 16.9
10.1
  5/7.5/10/15 mg/kg q2/3w 6 8
Zhuang, et al. (2015) [55] Retrospective
Jun 2011 - Dec 2014
Tianjin Cancer Hospital, Tianjin, China 14 56 6 8 Lung 11, Breast 1, Lymphoma 1, Gastric cancer 1 RT MRI, PET, pathology    5 mg/kg q3-4w 3 12
Xiang-Pan, L., et al. (2015) [49] Retrospective Wuhan, China 1 60   1 Lung WBRT/SRS MRI 12   7.5 mg/kg q3w 2  
Alessandretti, et al. (2013) [48] Retrospective Hospital São José, São Paulo, Brazil 2 49.5   2 Melanoma WBRT/SRS MRI 11.5   5,7.5 mg/kg q6/4w   
Zhuang, et al. (2019) [33] Prospective II CT
Dec 2016 - Feb 2019
Tianjin Cancer Hospital, Tianjin, China 21 55 (median, range 43–70) 11 10 Lung 17
Breast 2
Kidney cancer 2
SRT MRI 17.6   1 mg/kg q3w 3 22.7
Tanigawa, et al. (2019) [56] Retrospective Kagoshima University, Kagoshima, Japan 4 61.25 2 2 Lung STI (stereotactic irradiation) MRI 7.75   15 mg/kg q3–4w   
Ma, et al. (2017) [57] Retrospective Zhejiang University, Hangzhou, China 2 62   2 NSCLC SRS MRI 6.5   5 mg/kg q2w/7.5 mg/kg q3w 2.5 9
Glitza, I. et al. (2017) [58] Retrospective The University of Texas MD Anderson Cancer and Baylor College of Medicine, Houston, Texas, USA 7 57 5 2 Melanoma SRS/WBRT Surgery, MRI, pathology 8.14   5, 7.5, 10 mg/kg 3.7  
This study Systematic review   89   39 50       1-15 mg/kg q2-6w 2–6  
  1. Abbreviations: CT Clinical trial, No No of patients, M Male, F Female, WBRT Whole brain radiotherapy, SRS Stereotactic radiosurgery, SRT Stereotactic radiotherapy, EBRT External beam radiotherapy, RT Radiotherapy, FSRT Fractionated stereotactic radiotherapy, RN Radiation necrosis, BV Bevacizumab, Tx Treatment, NSCLC Non-small cell lung cancer, FT Fallopian tube, NSTC Non-seminomatous testicular cancer, MRI Magnetic resonance imaging, PET Positron, emission topography, q2w Every 2 weeks