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Table 1 General characteristics of the included studies

From: Bevacizumab for radiation necrosis following radiotherapy of brain metastatic disease: a systematic review & meta-analysis

Study

Study design & period

Location

No

Age

M

F

Primary pathology

Radiation

RN Diagnosis

RT to RN Diagnosis

RT to BV Tx

BV dosage

No. of cycles

Follow Up

Wang, et al. (2012) [50]

Retrospective

Mar 2010 - Jan 2012

Huashan Hospital, Fudan University, Shanghai, China

5

65

4

1

Colon 3

Lung 2

EBRT/SRS/FSRT

MRI, MRS, PET

 

4.6

7.5 mg/kg q2 week

2–6

6

Boothe, et al. (2013) [51]

Retrospective

3-year

Memorial Sloan- Kettering Cancer Center, New York, USA

11

58

4

7

Breast 5

NSCLC 6

WBRT/SRS

MRI, biopsy, PET

12.4

59.6 days

7.5 mg/kg q3w (1)

10 mg/kg q2w (8)

15 mg/kg q4/6w (2)

6

3.3

Furuse, et al. (2013) [52]

Retrospective

Jan 2009 - Oct 2010

Osaka Medical College, Takatsuki, Osaka, Japan

3

62

1

2

Unknown

SRS

MRI, MET-PET

 

11 (median)

5 mg/kg q2w

3

14.4

Yonezawa, et al. (2014) [53]

Prospective Nonrandomized

Jun 2010 - Sep 2011

Kizawa Memorial Hospital, Minokamo, Japan

2

52.5

1

1

Lung

WBRT/SRS/SRT

MRI, MET-PET

19

 

5 mg/kg q2w

6

 

Sadraei, et al. (2015) [54]

Retrospective Jul 2007 - Jun 2012

Cleveland Clinic, Cleveland, Ohio, USA

17

55.7

5

12

lung (9), breast (4), rectal (1), melanoma (1), NSTC (1), FT (1)),

WBRT/SRS

MRI, PET, biopsy

16.9

10.1

 

5/7.5/10/15 mg/kg q2/3w

6

8

Zhuang, et al. (2015) [55]

Retrospective

Jun 2011 - Dec 2014

Tianjin Cancer Hospital, Tianjin, China

14

56

6

8

Lung 11, Breast 1, Lymphoma 1, Gastric cancer 1

RT

MRI, PET, pathology

  

5 mg/kg q3-4w

3

12

Xiang-Pan, L., et al. (2015) [49]

Retrospective

Wuhan, China

1

60

 

1

Lung

WBRT/SRS

MRI

12

 

7.5 mg/kg q3w

2

 

Alessandretti, et al. (2013) [48]

Retrospective

Hospital São José, São Paulo, Brazil

2

49.5

 

2

Melanoma

WBRT/SRS

MRI

11.5

 

5,7.5 mg/kg q6/4w

  

Zhuang, et al. (2019) [33]

Prospective II CT

Dec 2016 - Feb 2019

Tianjin Cancer Hospital, Tianjin, China

21

55 (median, range 43–70)

11

10

Lung 17

Breast 2

Kidney cancer 2

SRT

MRI

17.6

 

1 mg/kg q3w

3

22.7

Tanigawa, et al. (2019) [56]

Retrospective

Kagoshima University, Kagoshima, Japan

4

61.25

2

2

Lung

STI (stereotactic irradiation)

MRI

7.75

 

15 mg/kg q3–4w

  

Ma, et al. (2017) [57]

Retrospective

Zhejiang University, Hangzhou, China

2

62

 

2

NSCLC

SRS

MRI

6.5

 

5 mg/kg q2w/7.5 mg/kg q3w

2.5

9

Glitza, I. et al. (2017) [58]

Retrospective

The University of Texas MD Anderson Cancer and Baylor College of Medicine, Houston, Texas, USA

7

57

5

2

Melanoma

SRS/WBRT

Surgery, MRI, pathology

8.14

 

5, 7.5, 10 mg/kg

3.7

 

This study

Systematic review

 

89

 

39

50

     

1-15 mg/kg q2-6w

2–6

 
  1. Abbreviations: CT Clinical trial, No No of patients, M Male, F Female, WBRT Whole brain radiotherapy, SRS Stereotactic radiosurgery, SRT Stereotactic radiotherapy, EBRT External beam radiotherapy, RT Radiotherapy, FSRT Fractionated stereotactic radiotherapy, RN Radiation necrosis, BV Bevacizumab, Tx Treatment, NSCLC Non-small cell lung cancer, FT Fallopian tube, NSTC Non-seminomatous testicular cancer, MRI Magnetic resonance imaging, PET Positron, emission topography, q2w Every 2 weeks