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Fig. 2 | BMC Cancer

Fig. 2

From: Metabolic alterations in meningioma reflect the clinical course

Fig. 2

a In the upper plot, the silhouette widths of both clusters are shown ordered by different cluster subgroups. In the middle panel, a heatmap illustrate the metabolic intensity of the top ranked metabolites. At the bottom panel, the information on clinical properties is available. These are color-coded and explained in the side panel. b In the upper panel, the plot illustrates the optimal number of clusters. The optimal number of clusters was achieved by PAM clustering from 2 to 10 number of clusters by calculating the mean silhouette widths. In the bottom panel, a network analysis of the metabolic pathways highly enriched in cluster 1 and 2 respectively is given. c A weighted correlation network analysis (WGNC) was performed to explore the associated clinical features and molecular/metabolic, further detailed interpretation of all identified modules is given in the supplementary data

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