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Table 3 Cox proportional hazards regression analyses of overall survival according to tumor stage

From: Preoperative nutritional risk index and postoperative one-year skeletal muscle loss can predict the prognosis of patients with gastric adenocarcinoma: a registry-based study

Variables Stage 2 (N = 436) Stage 3 (N = 522)
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR 95% CI P-value HR 95% CI P-value HR 95% CI P-value HR 95% CI P-value
Clinicopathologic
 Age (continuous) 1.028 1.013–1.044 <  0.001     1.016 1.006–1.027 0.002    
 Sex (male) 1.232 0.868–1.749 0.243     1.224 0.943–1.590 0.130    
 BMI (continuous) 0.981 0.924–1.041 0.516     0.975 0.935–1.016 0.220    
 CCI (continuous) 1.386 1.227–1.566 <  0.001 1.154 1.016–1.310 0.028 1.161 1.063–1.268 <  0.001 1.335 1.132–1.573 <  0.001
 Operation type (open) 1.022 0.659–1.584 0.924     1.644 0.874–3.093 0.123    
 Gastrectomy type (total) 1.190 0.851–1.664 0.309     1.139 0.895–1.449 0.290    
 Tumor size (continuous) 1.075 1.023–1.130 0.005     1.061 1.028–1.096 <  0.001    
 Tumor location (upper vs. others) 1.024 0.842–1.246 0.814     1.072 0.942–1.220 0.293    
 Lauren’s classification (other types vs. intestinal) 0.865 0.685–1.092 0.224     0.915 0.780–1.073 0.275    
 Recurrence 14.203 10.027–20.118 <  0.001 12.748 8.946–18.167 <  0.001 12.486 9.275–16.808 <  0.001 17.841 12.542–25.378 <  0.001
Preop. Body/Nutrition (as a continuous variable)
 SMI 0.998 0.987–1.010 0.801     1.000 0.995–1.007 0.746    
 SFA 0.997 0.993–0.999 0.036 0.997 0.994–0.999 0.044 0.997 0.995–0.999 0.008    
 VFA 1.000 0.997–1.003 0.961     1.000 0.998–1.002 0.866    
 NRI 0.957 0.936–0.978 <  0.001 0.971 0.948–0.995 0.019 0.968 0.953–0.983 <  0.001 0.973 0.956–0.991 0.004
Body/Nutrition change (as a continuous variable)
 dSMI 1.011 0.967–1.057 0.619     1.038 1.013–1.065 0.003 1.042 1.015–1.069 0.002
 dSFA 1.001 0.997–1.005 0.536     0.999 0.996–1.002 0.614    
 dVFA 1.001 0.997–1.005 0.518     0.999 0.996–1.002 0.367    
 dNRI 1.001 0.992–1.011 0.784     1.008 0.998–1.019 0.103    
  1. Abbreviations: HR Hazards ratio, CI Confidence interval, CCI Charlson comorbidity index; Preop., preoperative, SMA Skeletal muscle area, SMI Skeletal muscle index, SFA subcutaneous fat area, VFA Visceral fat area, NRI Nutritional risk index, dSMA Difference in SMA between before and one year after surgery, dSMI Difference in SMI between before and one year after surgery, dNRI Difference in NRI between before and one year after surgery