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Table 3 Cox proportional hazards regression analyses of overall survival according to tumor stage

From: Preoperative nutritional risk index and postoperative one-year skeletal muscle loss can predict the prognosis of patients with gastric adenocarcinoma: a registry-based study

Variables

Stage 2 (N = 436)

Stage 3 (N = 522)

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR

95% CI

P-value

HR

95% CI

P-value

HR

95% CI

P-value

HR

95% CI

P-value

Clinicopathologic

 Age (continuous)

1.028

1.013–1.044

<  0.001

   

1.016

1.006–1.027

0.002

   

 Sex (male)

1.232

0.868–1.749

0.243

   

1.224

0.943–1.590

0.130

   

 BMI (continuous)

0.981

0.924–1.041

0.516

   

0.975

0.935–1.016

0.220

   

 CCI (continuous)

1.386

1.227–1.566

<  0.001

1.154

1.016–1.310

0.028

1.161

1.063–1.268

<  0.001

1.335

1.132–1.573

<  0.001

 Operation type (open)

1.022

0.659–1.584

0.924

   

1.644

0.874–3.093

0.123

   

 Gastrectomy type (total)

1.190

0.851–1.664

0.309

   

1.139

0.895–1.449

0.290

   

 Tumor size (continuous)

1.075

1.023–1.130

0.005

   

1.061

1.028–1.096

<  0.001

   

 Tumor location (upper vs. others)

1.024

0.842–1.246

0.814

   

1.072

0.942–1.220

0.293

   

 Lauren’s classification (other types vs. intestinal)

0.865

0.685–1.092

0.224

   

0.915

0.780–1.073

0.275

   

 Recurrence

14.203

10.027–20.118

<  0.001

12.748

8.946–18.167

<  0.001

12.486

9.275–16.808

<  0.001

17.841

12.542–25.378

<  0.001

Preop. Body/Nutrition (as a continuous variable)

 SMI

0.998

0.987–1.010

0.801

   

1.000

0.995–1.007

0.746

   

 SFA

0.997

0.993–0.999

0.036

0.997

0.994–0.999

0.044

0.997

0.995–0.999

0.008

   

 VFA

1.000

0.997–1.003

0.961

   

1.000

0.998–1.002

0.866

   

 NRI

0.957

0.936–0.978

<  0.001

0.971

0.948–0.995

0.019

0.968

0.953–0.983

<  0.001

0.973

0.956–0.991

0.004

Body/Nutrition change (as a continuous variable)

 dSMI

1.011

0.967–1.057

0.619

   

1.038

1.013–1.065

0.003

1.042

1.015–1.069

0.002

 dSFA

1.001

0.997–1.005

0.536

   

0.999

0.996–1.002

0.614

   

 dVFA

1.001

0.997–1.005

0.518

   

0.999

0.996–1.002

0.367

   

 dNRI

1.001

0.992–1.011

0.784

   

1.008

0.998–1.019

0.103

   
  1. Abbreviations: HR Hazards ratio, CI Confidence interval, CCI Charlson comorbidity index; Preop., preoperative, SMA Skeletal muscle area, SMI Skeletal muscle index, SFA subcutaneous fat area, VFA Visceral fat area, NRI Nutritional risk index, dSMA Difference in SMA between before and one year after surgery, dSMI Difference in SMI between before and one year after surgery, dNRI Difference in NRI between before and one year after surgery
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BMC Cancer

ISSN: 1471-2407

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