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Table 2 Cox proportional hazards regression analyses of overall survival according to tumor recurrence

From: Preoperative nutritional risk index and postoperative one-year skeletal muscle loss can predict the prognosis of patients with gastric adenocarcinoma: a registry-based study

Variables Whole group (N = 958) Recurrence group (N = 293)
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR 95% CI P-value HR 95% CI P-value HR 95% CI P-value HR 95% CI P-value
Clinicopathologic
 Age (continuous) 1.019 1.011–1.028 <  0.001     1.002 0.992–1.012 0.701    
 Sex (male) 1.242 1.007–1.531 0.043     1.009 0.785–1.297 0.943    
 BMI (continuous) 0.968 0.935–1.001 0.061     0.999 0.960–1.039 0.955    
 CCI (continuous) 1.223 1.138–1.314 <  0.001 1.173 1.082–1.272 <  0.001 1.068 0.977–1.169 0.150    
 TNM stage (stage 3) 1.927 1.573–2.362 <  0.001 1.324 1.054–1.663 0.016 1.528 1.175–1.987 0.002 1.312 0.998–1.724 0.051
 Operation type (open) 1.458 1.027–2.072 0.035     1.308 0.845–2.024 0.229    
 Gastrectomy type (total) 1.240 1.020–1.506 0.030     1.109 0.875–1.405 0.393    
 Tumor size (continuous) 1.079 1.052–1.108 < 0.001     1.022 0.990–1.055 0.173    
 Tumor location (upper vs. others) 1.058 0.949–1.181 0.310     1.033 0.921–1.159 0.575    
 Lauren’s classification (other types vs. intestinal) 0.929 0.814–1.060 0.272     1.245 1.073–1.445 0.004 1.157 0.989–1.354 0.069
 Recurrence 13.992 11.197–17.486 <  0.001 16.838 13.089–21.662 <  0.001 NA NA NA NA NA NA
Preop. Body/Nutrition (as a continuous variable)
 SMI 1.000 0.994–1.006 0.965     1.001 0.995–1.007 1.001    
 SFA 0.997 0.995–0.999 <  0.001 0.998 0.996–1.000 0.075 0.999 0.997–1.001 0.497    
 VFA 1.000 0.998–1.002 0.864     0.999 0.997–1.001 0.447    
 NRI 0.960 0.948–0.973 <  0.001 0.976 0.962–0.991 0.002 0.981 0.966–0.996 0.014 0.966 0.950–0.983 <  0.001
Body/Nutrition change (as a continuous variable)
 dSMI 1.043 1.019–1.066 <  0.001 1.060 1.035–1.085 <  0.001 1.045 1.019–1.071 <  0.001 1.045 1.019–1.073 <  0.001
 dSFA 1.000 0.998–1.003 0.816     1.004 1.002–1.007 0.002 1.005 1.002–1.008 0.002
 dVFA 1.000 0.998–1.002 0.881     1.001 0.998–1.003 0.660    
 dNRI 1.000 0.993–1.006 0.917     1.004 0.995–1.002 0.406    
  1. Abbreviations: HR Hazards ratio, CI Confidence interval, CCI Charlson comorbidity index, Preop Preoperative, SMA Skeletal muscle area, SMI Skeletal muscle index, SFA subcutaneous fat area, VFA Visceral fat area, NRI Nutritional risk index, dSMA Difference in SMA between before and one year after surgery, dSMI Difference in SMI between before and one year after surgery, dNRI Difference in NRI between before and one year after surgery