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Table 3 Multivariable analysis stratifying by sex using cox regression and Fine&Gray regression models for predicting CSS in 665 localized RCC patients

From: Distinct effect of body mass index by sex as a prognostic factor in localized renal cell carcinoma treated with nephrectomy ~ data from a multi-institutional study in Japan ~

Variables

Male

Female

Cox regression model

Fine&Gray regression model

Cox regression model

Fine&Gray regression model

HR

95% CI

P value

SHR

95% CI

P value

HR

95% CI

P value

SHR

95% CI

P value

Age (<65 vs ≥65 years)

0.74

0.38-1.45

0.381

0.55

0.25-1.19

0.127

2.20

0.80-6.01

0.124

0.71

0.15-3.36

0.665

ECOG Performance Status (0 vs ≥1)

4.28

1.86-9.86

<0.001*

4.13

1.74-9.76

0.001*

5.77

1.91-17.46

0.002*

4.21

1.33-13.36

0.015*

Histological type (Clear cell vs others)

0.79

0.27-2.35

0.67

0.80

0.24-2.66

0.717

3.19

0.84-12.15

0.089

0.70

0.12-3.90

0.68

Pathological stage (1-2 vs >3)

4.20

2.18-8.08

<0.001*

4.34

2.04-9.24

<0.001*

3.20

1.17-8.75

0.024*

3.93

1.10-13.96

0.035*

Tumor size (<4 vs ≥4cm)

8.98

3.13-25.75

<0.001*

4.14

1.57-10.95

0.004*

2.28

0.58-9.02

0.238

10.44

0.91-119.2

0.059

BMI (<25 vs >25)

0.37

0.14-0.96

0.041*

0.20

0.06-0.72

0.014*

0.76

0.23-2.48

0.65

0.52

0.07-3.77

0.518

  1. CSS cancer-specific survival, OR odds rario, CI confidence interval, SHR sub-hazard ratio, ECOG eastern cooperative oncology group, BMI body mass index, * denotes p < 0.05