Table 1 The main characteristics of the included studies in the meta-analysis

1

Ju L (2016) [20]

China

BCAR4

168

IIA-IIB/III

48

70

tissue

qRT–PCR

median

Multivariate analysis

OS

3.22 (0.89, 7.88)

2

Chen F (2016) [21]

China

BCAR4

60

I-III

13

60

tissue

qRT–PCR

median

N/A

OS/RFS

1.83 (0.68, 4.96)

3

Ruan R (2018) [22]

China

CCAT2

50

IA-III

16

70

tissue

qRT–PCR

median

N/A

OS

1.30 (0.60, 2.84)

4

Yan L (2018) [23]

China

CCAT2

40

N/A

N/A

60

tissue

qRT–PCR

N/A

N/A

OS/RFS

3.57 (1.25, 5.31)

5

Jiang N (2017) [24]

China

DANCR

34

N/A

18

60

tissue

qRT–PCR

N/A

Multivariate analysis

OS/DFS

1.08 (1.23, 5.79)

6

Wang Y (2018) [25]

China

DANCR

95

I-III

58

60

tissue

qRT–PCR

Optimal

N/A

OS

2.4 (0.85, 3.25)

7

Fei D (2018) [26]

China

FER1L4

48

I-IV

10

60

tissue

qRT–PCR

median

N/A

OS/PFS

0.45 (0.17, 0.97)

8

Chen Z (2018) [27]

China

FER1L4

73

I-IV

25

60

tissue

qRT–PCR

N/A

N/A

OS/PFS

0.43 (0.05, 0.86)

9

Ren Z (2019) [28]

China

FOXD2-AS1

35

I-III

N/A

60

tissue

qRT–PCR

N/A

N/A

OS

1.66 (0.47, 5.82)

10

Zhang H (2019) [29]

China

FOXD2-AS1

40

N/A

N/A

70

tissue

qRT–PCR

N/A

N/A

OS

1.55 (0.3, 7.86)

11

Cai L (2017) [30]

China

HNF1A-AS1

72

IIA-III

42

<60

tissue

qRT–PCR

median

Multivariate analysis

OS

2.63 (1.55, 5.65)

12

Zhao H (2016) [31]

China

HNF1A-AS1

43

I-III

11

60

tissue

qRT–PCR

median

Multivariate analysis

OS

2.64 (1.39, 7.42)

13

Cao K (2019) [32]

China

HOXA11-AS

61

I-III

17

60

tissue

qRT–PCR

median

N/A

OS

1.5 (0.43, 5.26)

14

Cui M (2017) [33]

China

HOXA11-AS

51

I-III

13

60

tissue

qRT–PCR

median

N/A

OS

3.22 (0.31, 33.42)

15

Gu W (2018) [34]

China

HOXD-AS1

43

I-III

N/A

60

tissue

qRT–PCR

N/A

N/A

OS

1.39 (0.28, 7.02)

16

Qu Y (2018) [35]

China

HOXD-AS1

46

I-IV

11

60

tissue

qRT–PCR

median

N/A

OS

1.63 (1.19, 2.96)

17

Maciel Uzan (2016) [36]

Brazil

HULC

33

I-IV

10

100

tissue

qRT–PCR

optimal

Multivariate analysis

OS/EFS

22.01 (2.26, 16.13)

18

Sun X (2015) [37]

China

HULC

78

IIA-III

21

60

tissue

qRT–PCR

median

Multivariate analysis

OS

2.28 (1.48, 5.43)

19

He W (2019) [38]

China

LSINCT5

124

I-III

22

72

tissue

qRT–PCR

median

Multivariate analysis

OS

1.68 (1.02, 2.76)

20

Kong D (2018) [39]

China

LSINCT5

42

I-IV

18

60

tissue

qRT–PCR

N/A

N/A

OS/DFS

1.39 (1.13, 5.68)

21

Chen Y (2018) [40]

China

MALAT1

68

N/A

N/A

60

tissue

qRT–PCR

N/A

Multivariate analysis

OS/DFS

1.73 (1.10, 2.54)

22

Gao K (2016) [41]

China

MALAT1

162

IIA-III

44

70

tissue

qRT–PCR

median

Multivariate analysis

OS

2.8 (1.76, 7.84)

23

Huo Y (2017) [42]

China

MALAT1

68

I-IV

22

80

serum

qRT–PCR

median

N/A

OS/PFS

3.33 (1.43, 4.91)

24

Li Q (2017) [43]

China

MALAT1

64

I-IV

33

60

tissue

qRT–PCR

optimal

Multivariate analysis

OS

2.22 (0.3, 16.44)

25

Sun Y (2018) [44]

China

MALAT1

42

I-III

20

60

tissue

qRT–PCR

N/A

N/A

OS

2.2 (1.15, 4.21)

26

Sun Z (2019) [45]

China

MALAT1

76

I-III

46

120

tissue

qRT–PCR

N/A

N/A

OS

2.51 (0.79, 7.99)

27

Wang J (2017) [46]

China

MALAT1

70

N/A

N/A

<60

tissue

qRT–PCR

N/A

N/A

OS

2.34 (0.55, 9.92)

28

Wang Y (2017b) [47]

China

MALAT1

55

I-III

31

60

tissue

qRT–PCR

median

N/A

OS

1.01 (0.25, 4.03)

29

Shen B (2019) [48]

China

MEG3

204

I-III

80

50

tissue

qRT–PCR

median

Multivariate analysis

OS

0.56 (0.36, 0.87)

30

Tian Z (2015) [49]

China

MEG3

64

I-III

17

60

tissue

qRT–PCR

median

Multivariate analysis

OS

0.45 (0.11, 1.81)

31

Ji S (2019) [50]

China

NEAT1

72

N/A

N/A

160

tissue

qRT–PCR

median

N/A

OS

2.09 (0.84, 5.22)

32

Li Y (2018) [51]

China

NEAT1

76

I-III

38

60

tissue

qRT–PCR

median

N/A

OS

1.88 (0.47, 7.49)

33

Tan H (2019) [52]

China

NEAT1

47

I-III

11

50

tissue

qRT–PCR

median

N/A

OS

1.84 (0.61, 5.57)

34

Zhu K (2019) [53]

China

OIP5-AS1

80

N/A

N/A

60

tissue

qRT–PCR

N/A

N/A

OS

1.48 (0.42, 5.15)

35

Dai J (2018) [54]

China

OIP5-AS1

48

I-III

N/A

60

tissue

qRT–PCR

median

N/A

OS

1.77 (1.17, 2.94)

36

Zhang C (2016) [55]

China

ODRUL

60

N/A

12

80

tissue

qRT–PCR

median

N/A

OS

1.21 (0.36, 4.06)

37

Zhu K (2017) [56]

China

ODRUL

80

N/A

48

100

tissue

qRT–PCR

N/A

N/A

OS

2.35 (1.08, 5.15)

38

Huang J (2018) [57]

China

PCAT1

62

I-III

35

60

tissue

qRT–PCR

N/A

Multivariate analysis

OS/PFS

1.53 (1.37, 2.92)

39

Zhang X (2018) [58]

China

PCAT1

30

I-III

17

60

tissue

qRT–PCR

mean

Multivariate analysis

OS

4.01 (1.56, 4.57)

40

Song J (2017) [59]

China

PVT1

46

I-III

N/A

70

tissue

qRT–PCR

mean

N/A

OS

1.63 (0.05, 5.39)

41

Zhou Q (2016) [60]

China

PVT1

53

N/A

13

60

tissue

qRT–PCR

N/A

N/A

OS

1.70 (0.66, 4.37)

42

Zhou B (2018) [61]

China

SNHG12

64

N/A

N/A

80

tissue

qRT–PCR

N/A

N/A

OS

2.10 (0.66, 6.64)

43

Zhou S (2018) [62]

China

SNHG12

31

I-III

21

60

tissue

qRT–PCR

mean

N/A

OS

1.52 (1.00, 18.48)

44

Liao S (2019) [63]

China

SNHG16

96

I-III

51

60

tissue

qRT–PCR

mean

Multivariate analysis

OS

1.58 (0.65, 3.86)

45

Wang X (2019) [64]

China

SNHG16

65

I-III

28

60

tissue

qRT–PCR

median

N/A

OS

2.62 (0.82, 8.36)

46

Wang W (2018) [65]

China

SNHG20

32

I-III

N/A

60

tissue

qRT–PCR

median

N/A

OS

1.94 (1.19, 3.17)

47

Zhang J (2018) [66]

China

SNHG20

140

I-III

24

72

tissue

qRT–PCR

N/A

Multivariate analysis

OS

2.05 (0.53, 7.92)

48

Chen X (2019) [67]

China

TP73-AS1

132

I-III

22

72

tissue

qRT–PCR

N/A

Multivariate analysis

OS

1.89 (1.15, 3.13)

49

Yang G (2018) [68]

China

TP73-AS1

46

I-III

11

50

tissue

qRT–PCR

mean

N/A

OS

1.98 (0.61, 6.28)

50

Ma B (2016) [69]

China

TUG1

76

I-III

36

60

tissue

qRT–PCR

optomal

Multivariate analysis

OS/PFS

2.77 (1.29, 5.98)

51

Sheng K (2019) [70]

China

TUG1

40

N/A

26

60

plasma

qRT–PCR

median

N/A

OS

1.59 (1.36, 1.97)

52

Wang Q (2018) [71]

China

TUG1

94

IIA -III

26

70

tissue

qRT–PCR

median

Multivariate3analysis

OS

1.10 (0.96, 15.35)

53

Wang Y (2017a) [72]

China

TUG1

44

I-III

28

120

tissue

qRT–PCR

N/A

N/A

OS

2.12 (1.44, 3.67)

54

Yu X (2019) [73]

China

TUG1

40

I-III

11

60

tissue

qRT–PCR

N/A

N/A

OS/RFS

1.44 (1.15, 2.54)

55

Li W (2016) [74]

China

UCA1

135

I-III

34

60

tissue

qRT–PCR

median

Multivariate analysis

OS

2.19 (0.87, 5.55)

56

Wen J (2017) [75]

China

UCA1

151

IIA -III

79

60

tissue

qRT–PCR

optimal

Multivariate analysis

OS

2.52 (1.34, 4.83)

57

Li G (2017) [76]

China

XIST

145

I-IV

44

60

tissue

qRT–PCR

N/A

N/A

OS

1.75 (1.00, 3.06)

58

Wang W (2019) [77]

China

XIST

64

IA -III

15

70

tissue

qRT–PCR

median

N/A

OS

1.92 (1.25, 3.29)

59

Yang C (2018) [78]

China

XIST

40

I-III

N/A

60

tissue

qRT–PCR

N/A

N/A

OS

3.07 (1.84, 11.15)

60

Zhang R (2017) [79]

China

XIST

50

N/A

26

60

tissue

qRT–PCR

N/A

N/A

OS

1.59 (1.38, 2.88)

61

Li N (2017) [80]

China

ZFAS1

53

I-III

16

60

tissue

qRT–PCR

median

Multivariate analysis

OS/RFS

1.14 (0.23, 5.61)

62

Liu G (2017) [81]

China

ZFAS1

50

N/A

N/A

30

tissue

qRT–PCR

median

N/A

OS

1.59 (0.64, 3.95)