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Fig. 5 | BMC Cancer

Fig. 5

From: Reprogramming of glutamine metabolism via glutamine synthetase silencing induces cisplatin resistance in A2780 ovarian cancer cells

Fig. 5

A model for CDDP resistance development via reprogramming of glutamine metabolism in ovarian cancer cells. In CDDP-sensitive cancer cells, both GLS and GS are expressed, and low levels of GSH are produced from glutamate. In contrast, in CDDP-resistant cells, GS expression is suppressed by DNA methylation, whereas GLS expression is maintained, and thereby high levels of GSH are produced. This reprogramming of glutamine metabolism causes CDDP resistance

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BMC Cancer

ISSN: 1471-2407

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