Variation rs9929218 and risk of the colorectal Cancer and adenomas: A meta-analysis

BMC Cancer

Table 2 Stratified analyses of the rs9929218 polymorphism on CRC/CRA risk

Variables	N^a	Case/Control	GG vs AA			AG vs AA			AG/GG vs AA			GG vs AA/AG
Variables	N^a	Case/Control	OR(95%CI)	P^b	I²(%)	OR(96%CI)	P^b	I²(%)	OR(97%CI)	P^b	I²(%)	OR(98%CI)	P^b	I²(%)
Total	13	8192/11590	1.14 (1.00–1.28)^c	0.042	0	1.12 (0.99–1.27)	0.069	0	1.13 (1.00–1.27)^c	0.044	0	1.03 (0.97–1.09)	0.334	2.2
Disease type
CRC	10	6191/9314	1.10 (0.95–1.27)	0.207	0	1.11 (0.95–1.29)	0.201	6.8	1.10 (0.96–1.27)	0.162	0	1.00 (0.94–1.07)	0.909	0
CRA	3	2001/2276	1.25 (0.99–1.58)	0.065	0	1.15 (0.90–1.46)	0.267	0	1.20 (0.96–1.52)	0.113	0	1.12 (0.99–1.26)	0.075	0
Ethnicity
European	6	4540/5874	1.21 (1.04–1.42)^c	0.016	0	1.24 (1.06–1.45)^c	0.008	0	1.22 (1.05–1.42)^c	0.010	0	1.01 (0.93–1.10)	0.786	0
Asian	5	2751/4446	1.00 (0.78–1.29)	0.996	0	0.97 (0.75–1.26)	0.827	0	0.99 (0.77–1.27)	0.945	0	1.04 (0.89–1.20)	0.642	50.1
Other	2	901/1270	1.08 (0.58–2.00)	0.806	74.3	0.94 (0.58–1.53)	0.818	55.5	1.02 (0.58–1.78)	0.945	70.6	1.13 (0.90–1.43)	0.299	44.6
Source of controls
hospital	7	4706/5575	1.13 (0.96–1.34)	0.141	0	1.09 (0.92–1.30)	0.318	0	1.12 (0.95–1.32)	0.181	0	1.06 (0.94–1.19)	0.332	47.2
population	4	1332/3827	1.20 (0.90–1.61)	0.213	0	1.21 (0.90–1.63)	0.206	0	1.21 (0.91–1.61)	0.190	0	1.03 (0.90–1.17)	0.653	0
mixed	2	2154/2188	1.03 (0.66–1.59)	0.910	67.3	1.02 (0.58–1.79)	0.951	78.6	1.02 (0.62–1.66)	0.941	75.4	0.99 (0.88–1.11)	0.817	0

a Number of comparisons
b P value of Q-test for heterogeneity test
c Random-effects model was used when P value for heterogeneity test > 0.05; otherwise, fix-effects model was used
CRC Colorectal cancer
CRA Colorectal adenomas

ISSN: 1471-2407