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Table 2 Multivariate Cox regression analyses on patients with HCC from SEER database

From: Effect of prior cancer on survival of hepatocellular carcinoma: implications for clinical trial eligibility criteria

Multivariate Cox regression analyses Overall survival Cancer-specific survival
HRa (95%CI) P value HRa (95%CI) P value
Age (years) 1.013 (1.010–1.017) < 0.001 1.015 (1.011–1.020) < 0.001
Sex
 Female Reference   Reference  
 Male 0.975 (0.903–1.054) 0.526 0.950 (0.867–1.040) 0.265
Race
 White Reference   Reference  
 Black 1.040 (0.947–1.142) 0.412 1.002 (0.896–1.121) 0.976
 Others/unknown 0.741 (0.671–0.817) < 0.001 0.752 (0.670–0.843) < 0.001
Tumor size (mm)
 0 < x ≤ 20 Reference   Reference  
 20 < x ≤ 50 1.300 (1.149–1.471) < 0.001 1.396 (1.193–1.633) < 0.001
 50 < x ≤ 100 1.608 (1.401–1.847) < 0.001 1.860 (1.567–2.207) < 0.001
 x > 100 2.312 (1.982–2.698) < 0.001 2.797 (2.321–3.371) < 0.001
 Unknown 2.008 (1.733–2.326) < 0.001 2.253 (1.878–2.701) < 0.001
AJCC stage
 I Reference   Reference  
 II 1.163 (1.057–1.279) 0.002 1.250 (1.113–1.404) < 0.001
 III 1.861 (1.685–2.056) < 0.001 2.088 (1.862–2.341) < 0.001
 IV 2.517 (2.235–2.834) < 0.001 2.886 (2.519–3.306) < 0.001
 Unknown 1.407 (1.257–1.576) < 0.001 1.534 (1.341–1.755) < 0.001
Pathological Grade
 Well differentiation Reference   Reference  
 Moderately differentiation 1.116 (1.001–1.245) 0.048 1.199 (1.054–1.363) 0.006
 Poorly differentiation / undifferentiation 1.569 (1.372–1.794) < 0.001 1.668 (1.428–1.949) < 0.001
 Unknown 1.277 (1.166–1.398) < 0.001 1.266 (1.137–1.410) < 0.001
Curative treatment
 No/unknown Reference   Reference  
 Yes 0.429 (0.394–0.467) < 0.001 0.401 (0.362–0.445) < 0.001
Radiotherapy
 No/unknown Reference   Reference  
 Yes 0.934 (0.836–1.044) 0.231 0.960 (0.843–1.093) 0.534
Systemic therapy
 No/unknown Reference   Reference  
 Yes 0.904 (0.848–0.965) 0.002 0.976 (0.905–1.053) 0.534
Prior cancer history
 No Reference   Reference  
 Yes 1.024 (0.961–1.092) 0.462 0.736 (0.682–0.793) < 0.001
  1. aHR Hazard ratio