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Table 2 Multivariate Cox regression analyses on patients with HCC from SEER database

From: Effect of prior cancer on survival of hepatocellular carcinoma: implications for clinical trial eligibility criteria

Multivariate Cox regression analyses

Overall survival

Cancer-specific survival

HRa (95%CI)

P value

HRa (95%CI)

P value

Age (years)

1.013 (1.010–1.017)

< 0.001

1.015 (1.011–1.020)

< 0.001

Sex

 Female

Reference

 

Reference

 

 Male

0.975 (0.903–1.054)

0.526

0.950 (0.867–1.040)

0.265

Race

 White

Reference

 

Reference

 

 Black

1.040 (0.947–1.142)

0.412

1.002 (0.896–1.121)

0.976

 Others/unknown

0.741 (0.671–0.817)

< 0.001

0.752 (0.670–0.843)

< 0.001

Tumor size (mm)

 0 < x ≤ 20

Reference

 

Reference

 

 20 < x ≤ 50

1.300 (1.149–1.471)

< 0.001

1.396 (1.193–1.633)

< 0.001

 50 < x ≤ 100

1.608 (1.401–1.847)

< 0.001

1.860 (1.567–2.207)

< 0.001

 x > 100

2.312 (1.982–2.698)

< 0.001

2.797 (2.321–3.371)

< 0.001

 Unknown

2.008 (1.733–2.326)

< 0.001

2.253 (1.878–2.701)

< 0.001

AJCC stage

 I

Reference

 

Reference

 

 II

1.163 (1.057–1.279)

0.002

1.250 (1.113–1.404)

< 0.001

 III

1.861 (1.685–2.056)

< 0.001

2.088 (1.862–2.341)

< 0.001

 IV

2.517 (2.235–2.834)

< 0.001

2.886 (2.519–3.306)

< 0.001

 Unknown

1.407 (1.257–1.576)

< 0.001

1.534 (1.341–1.755)

< 0.001

Pathological Grade

 Well differentiation

Reference

 

Reference

 

 Moderately differentiation

1.116 (1.001–1.245)

0.048

1.199 (1.054–1.363)

0.006

 Poorly differentiation / undifferentiation

1.569 (1.372–1.794)

< 0.001

1.668 (1.428–1.949)

< 0.001

 Unknown

1.277 (1.166–1.398)

< 0.001

1.266 (1.137–1.410)

< 0.001

Curative treatment

 No/unknown

Reference

 

Reference

 

 Yes

0.429 (0.394–0.467)

< 0.001

0.401 (0.362–0.445)

< 0.001

Radiotherapy

 No/unknown

Reference

 

Reference

 

 Yes

0.934 (0.836–1.044)

0.231

0.960 (0.843–1.093)

0.534

Systemic therapy

 No/unknown

Reference

 

Reference

 

 Yes

0.904 (0.848–0.965)

0.002

0.976 (0.905–1.053)

0.534

Prior cancer history

 No

Reference

 

Reference

 

 Yes

1.024 (0.961–1.092)

0.462

0.736 (0.682–0.793)

< 0.001

  1. aHR Hazard ratio
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