Table 1 Baseline characteristics of the patients with HCC from SEER database
Patient characteristics | Raw cohorts | PSM cohorts | ||||
|---|---|---|---|---|---|---|
No prior cancer (n = 44,789) | With prior cancer (n = 2642) | P value | No prior cancer (n = 2642) | With prior cancer (n = 2642) | P value | |
Age (years) | 62.57 ± 10.80 | 68.95 ± 9.77 | < 0.001 | 69.01 ± 9.84 | 68.95 ± 9.77 | 0.843 |
Sex | 0.852 | 0.472 | ||||
Female | 10,200 (22.8) | 597 (22.6) | 620 (23.5) | 597 (22.6) | ||
Male | 34,589 (77.2) | 2045 (77.4) | 2022 (76.5) | 2045 (77.4) | ||
Race | < 0.001 | 0.141 | ||||
White | 30,250 (67.5) | 1903 (72.0) | 1951 (73.8) | 1903 (72.0) | ||
Black | 5843 (13.0) | 386 (14.6) | 337 (12.8) | 386 (14.6) | ||
Others/unknown | 8717 (19.4) | 353 (13.4) | 354 (13.4) | 353 (13.4) | ||
Tumor size (mm) | 0.102 | 0.761 | ||||
0 < x ≤ 20 | 5733 (12.8) | 297 (11.2) | 290 (11.0) | 297 (11.2) | ||
20 < x ≤ 50 | 17,424 (38.9) | 1061 (40.2) | 1039 (39.3) | 1061 (40.2) | ||
50 < x ≤ 100 | 10,166 (22.7) | 628 (23.8) | 616 (23.3) | 628 (23.8) | ||
x > 100 | 4419 (9.9) | 257 (9.7) | 265 (10.0) | 257 (9.7) | ||
Unknown | 7047 (15.7) | 399 (15.1) | 432 (16.4) | 399 (15.1) | ||
AJCC stage | < 0.001 | 0.683 | ||||
I | 16,421 (36.6) | 1089 (41.2) | 1110 (41.6) | 1089 (41.2) | ||
II | 8861 (19.8) | 500 (18.9) | 507 (19.2) | 500 (18.9) | ||
III | 8483 (18.9) | 462 (17.4) | 481 (18.2) | 460 (17.4) | ||
IV | 4625 (10.3) | 228 (8.6) | 223 (8.4) | 228 (8.6) | ||
Unknown | 6399 (14.3) | 365 (13.8) | 331 (12.5) | 365 (13.8) | ||
Pathological grade | < 0.001 | 0.196 | ||||
Well differentiation | 5487 (12.3) | 450 (17.0) | 453 (17.1) | 450 (17.0) | ||
Moderately differentiation | 7452 (16.6) | 554 (21.0) | 517 (19.6) | 554 (21.0) | ||
Poorly differentiation / undifferentiation | 3381 (7.5) | 222 (8.4) | 193 (7.3) | 222 (8.4) | ||
Unknown | 28,469 (63.6) | 1416 (53.6) | 1479 (56.0) | 1416 (53.6) | ||
Curative treatment | 0.902 | 0.952 | ||||
No/unknown | 31,473 (70.3) | 1853 (70.1) | 1856 (70.2) | 1853 (70.1) | ||
Yes | 13,316 (29.8) | 789 (29.9) | 786 (29.8) | 789 (29.9) | ||
Radiotherapy | 0.004 | 0.097 | ||||
No/unknown | 41,244 (92.1) | 2391 (90.5) | 2426 (91.8) | 2391 (90.5) | ||
Yes | 3545 (7.9) | 251 (9.5) | 216 (8.2) | 251 (9.5) | ||
Systemic therapy | 0.068 | 0.088 | ||||
No/unknown | 25,853 (57.7) | 1478 (55.9) | 1539 (58.3) | 1478 (55.9) | ||
Yes | 18,936 (42.3) | 1164 (44.1) | 1103 (41.7) | 1164 (44.1) | ||