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Table 1 Baseline characteristics of the patients with HCC from SEER database

From: Effect of prior cancer on survival of hepatocellular carcinoma: implications for clinical trial eligibility criteria

Patient characteristics Raw cohorts PSM cohorts
No prior cancer (n = 44,789) With prior cancer (n = 2642) P value No prior cancer
(n = 2642)
With prior cancer
(n = 2642)
P value
Age (years) 62.57 ± 10.80 68.95 ± 9.77 < 0.001 69.01 ± 9.84 68.95 ± 9.77 0.843
Sex    0.852    0.472
 Female 10,200 (22.8) 597 (22.6)   620 (23.5) 597 (22.6)  
 Male 34,589 (77.2) 2045 (77.4)   2022 (76.5) 2045 (77.4)  
Race    < 0.001    0.141
 White 30,250 (67.5) 1903 (72.0)   1951 (73.8) 1903 (72.0)  
 Black 5843 (13.0) 386 (14.6)   337 (12.8) 386 (14.6)  
 Others/unknown 8717 (19.4) 353 (13.4)   354 (13.4) 353 (13.4)  
Tumor size (mm)    0.102    0.761
 0 < x ≤ 20 5733 (12.8) 297 (11.2)   290 (11.0) 297 (11.2)  
 20 < x ≤ 50 17,424 (38.9) 1061 (40.2)   1039 (39.3) 1061 (40.2)  
 50 < x ≤ 100 10,166 (22.7) 628 (23.8)   616 (23.3) 628 (23.8)  
 x > 100 4419 (9.9) 257 (9.7)   265 (10.0) 257 (9.7)  
 Unknown 7047 (15.7) 399 (15.1)   432 (16.4) 399 (15.1)  
AJCC stage    < 0.001    0.683
 I 16,421 (36.6) 1089 (41.2)   1110 (41.6) 1089 (41.2)  
 II 8861 (19.8) 500 (18.9)   507 (19.2) 500 (18.9)  
 III 8483 (18.9) 462 (17.4)   481 (18.2) 460 (17.4)  
 IV 4625 (10.3) 228 (8.6)   223 (8.4) 228 (8.6)  
 Unknown 6399 (14.3) 365 (13.8)   331 (12.5) 365 (13.8)  
Pathological grade    < 0.001    0.196
 Well differentiation 5487 (12.3) 450 (17.0)   453 (17.1) 450 (17.0)  
 Moderately differentiation 7452 (16.6) 554 (21.0)   517 (19.6) 554 (21.0)  
 Poorly differentiation / undifferentiation 3381 (7.5) 222 (8.4)   193 (7.3) 222 (8.4)  
 Unknown 28,469 (63.6) 1416 (53.6)   1479 (56.0) 1416 (53.6)  
Curative treatment    0.902    0.952
 No/unknown 31,473 (70.3) 1853 (70.1)   1856 (70.2) 1853 (70.1)  
 Yes 13,316 (29.8) 789 (29.9)   786 (29.8) 789 (29.9)  
Radiotherapy    0.004    0.097
 No/unknown 41,244 (92.1) 2391 (90.5)   2426 (91.8) 2391 (90.5)  
 Yes 3545 (7.9) 251 (9.5)   216 (8.2) 251 (9.5)  
Systemic therapy    0.068    0.088
 No/unknown 25,853 (57.7) 1478 (55.9)   1539 (58.3) 1478 (55.9)  
 Yes 18,936 (42.3) 1164 (44.1)   1103 (41.7) 1164 (44.1)