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Table 4 Univariate cox regression analysis of prognostic factors influencing overall survival and disease-free survival

From: Minimal invasive versus open esophagectomy for patients with esophageal squamous cell carcinoma after neoadjuvant treatments

Variables Overall survival Disease-free survival
HR 95% CI P HR 95% CI P
Age(y)
  ≤ 55 1    1   
  > 55 0.987 0.629–1.548 0.954 0.703 0.383–1.289 0.254
Sex
 Female 1    1   
 Male 2.275 1.135–4.559 0.021 2.089 0.820–5.320 0.122
Surgical approach
 Open surgery 1    1   
 MIE 0.557 0.358–0.867 0.010 0.618 0.337–1.134 0.120
Operation date
 2010.1–2013.12 1    1   
 2014.1–2016.12 0.891 0.587–1.352 0.588 0.954 0.513–1.771 0.880
Location
 Upper third 1    1   
 Middle third 0.972 0.581–1.608 0.915 2.083 1.007–4.307 0.048
 Lower third 1.134 0.632–2.032 0.674 0.726 0.248–2.124 0.558
Pathological T stage
 0 1    1   
 T1 2.367 1.181–4.743 0.015 1.219 0.354–4.202 0.754
 T2 1.401 0.742–2.646 0.298 1.999 0.907–4.410 0.086
 T3 2.531 1.559–4.110 < 0.001 1.584 0.760–3.303 0.220
Pathological N stage
 N0 1    1   
 N1 1.347 0.806–2.250 0.255 1.207 0.582–2.505 0.613
 N2 3.673 2.077–6.496 < 0.001 1.651 0.574–4.751 0.353
 N3 4.051 1.822–9.008 0.001 2.060 0.487–8.710 0.326
Grade
 Posttreatment change 1    1   
 G1 1.738 0.763–3.958 0.188 0.889 0.205–3.850 0.875
 G2 1.800 1.078–3.007 0.025 1.181 0.552–2.526 0.668
 G3 2.473 1.457–4.196 0.001 2.038 0.970–4.281 0.060
ypTNM stage
 I 1    1   
 II 1.431 0.699–2.930 0.327 1.618 0.680–3.851 0.277
 III 2.238 1.369–3.660 0.001 1.457 0.130–2.910 0.286
 IV 3.906 1.505–10.135 0.005 2.296 0.533–9.893 0.266
Neoadjuvant therapy
 Chemotherapy 1    1   
 Chemoradiation 0.732 0.470–1.141 0.168 1.160 0.617–2.182 0.645
Postoperative therapy
 No 1    1   
 Yes 0.503 0.319–0.794 0.003 0.111 0.056–0.218 < 0.001
  1. HR hazard ratio; CI confidence interval; MIE minimally invasive esophagectomy. G1 well differentiated; G2 moderately differentiated; G3 poorly differentiated