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Table 4 Univariate cox regression analysis of prognostic factors influencing overall survival and disease-free survival

From: Minimal invasive versus open esophagectomy for patients with esophageal squamous cell carcinoma after neoadjuvant treatments

Variables

Overall survival

Disease-free survival

HR

95% CI

P

HR

95% CI

P

Age(y)

  ≤ 55

1

  

1

  

  > 55

0.987

0.629–1.548

0.954

0.703

0.383–1.289

0.254

Sex

 Female

1

  

1

  

 Male

2.275

1.135–4.559

0.021

2.089

0.820–5.320

0.122

Surgical approach

 Open surgery

1

  

1

  

 MIE

0.557

0.358–0.867

0.010

0.618

0.337–1.134

0.120

Operation date

 2010.1–2013.12

1

  

1

  

 2014.1–2016.12

0.891

0.587–1.352

0.588

0.954

0.513–1.771

0.880

Location

 Upper third

1

  

1

  

 Middle third

0.972

0.581–1.608

0.915

2.083

1.007–4.307

0.048

 Lower third

1.134

0.632–2.032

0.674

0.726

0.248–2.124

0.558

Pathological T stage

 0

1

  

1

  

 T1

2.367

1.181–4.743

0.015

1.219

0.354–4.202

0.754

 T2

1.401

0.742–2.646

0.298

1.999

0.907–4.410

0.086

 T3

2.531

1.559–4.110

< 0.001

1.584

0.760–3.303

0.220

Pathological N stage

 N0

1

  

1

  

 N1

1.347

0.806–2.250

0.255

1.207

0.582–2.505

0.613

 N2

3.673

2.077–6.496

< 0.001

1.651

0.574–4.751

0.353

 N3

4.051

1.822–9.008

0.001

2.060

0.487–8.710

0.326

Grade

 Posttreatment change

1

  

1

  

 G1

1.738

0.763–3.958

0.188

0.889

0.205–3.850

0.875

 G2

1.800

1.078–3.007

0.025

1.181

0.552–2.526

0.668

 G3

2.473

1.457–4.196

0.001

2.038

0.970–4.281

0.060

ypTNM stage

 I

1

  

1

  

 II

1.431

0.699–2.930

0.327

1.618

0.680–3.851

0.277

 III

2.238

1.369–3.660

0.001

1.457

0.130–2.910

0.286

 IV

3.906

1.505–10.135

0.005

2.296

0.533–9.893

0.266

Neoadjuvant therapy

 Chemotherapy

1

  

1

  

 Chemoradiation

0.732

0.470–1.141

0.168

1.160

0.617–2.182

0.645

Postoperative therapy

 No

1

  

1

  

 Yes

0.503

0.319–0.794

0.003

0.111

0.056–0.218

< 0.001

  1. HR hazard ratio; CI confidence interval; MIE minimally invasive esophagectomy. G1 well differentiated; G2 moderately differentiated; G3 poorly differentiated