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Table 2 Characteristics of eligible studies for clinicopathological features

From: Prognostic values of tumoral MMP2 and MMP9 overexpression in breast cancer: a systematic review and meta-analysis

Author Year Country Sample size Cut-offa Protein T N M ER PR HER2 S G NOS
Talvensaari-Mattila [51] 1998 Finland 169 P > 1% MMP2   8
Talvensaari-Mattila [50] 1999 Finland 108 P > 1% MMP2       8
Talvensaari-Mattila [49] 2001 Finland 100 P > 1% MMP2        7
Scorilas 2011 Greece 210 HSCORE> 175 MMP9     7
Hirvonen [47] 2003 Finland 137 P > 1% MMP2        6
Nakopoulou 2003 Greece 135 P > 10% MMP2        6
Fan [45] 2003 China 66 SI ≥ 1 MMP2, MMP9       6
Talvensaari-Mattila [44] 2003 Finland 453 P > 1% MMP2    8
Li [19] 2004 China 270 P > 1% MMP2, MMP9        6
Rahko [23] 2004 Finland 168 P > 1% MMP9      7
Ban [52] 2004 China 60 SI ≥ 3 MMP2          7
Sivula 2005 Finland 194 P > 20% MMP2       7
Zhou [42] 2005 China 112 P > 5% MMP2      7
Mylona 2007 Greece 175 P > 20% MMP9     6
Hao 2007 China 76 SI ≥ 5 MMP9     7
Wu 2008 China 60 P > 50% MMP9     7
Sullu [22] 2011 Turkey 140 SI ≥ 5 MMP9   8
Zhao [18] 2013 China 127 SI ≥ 6 MMP9      6
Zeng [36] 2013 China 253 P > 20% MMP9     8
Wu 2014 China 41 SI ≥ 1 MMP9     7
Tang 2014 China 156 SI ≥ 6 MMP9   8
Min [32] 2014 Korea 177 SI ≥ 1, SI ≥ 5 MMP2, MMP9   7
Youssef 2014 Egypt 67 P > 10% MMP9   7
Huang [55] 2014 China 147 P > 10% MMP9         6
Ramos [29] 2016 Brazil 44 P > 10% MMP2   7
Li [16] 2017 China 80 P > 25% MMP2, MMP9        7
Yang [28] 2018 Korea 173 SI ≥ 2 MMP9   8
Zhang [56] 2019 China 127 SI ≥ 6 MMP9      7
Zhou [54] 2009 China 43 SI ≥ 3 MMP9      7
Joseph [27] 2020 British 675 SI MMP9     8
  1. aCut-off for overexpression of matrix metalloproteinases in tumor cells by immunohistochemistry
  2. P percentage of stained cells, SI staining index considering both percentage and intensity of staining, T tumor size, N lymph node status, M distant metastasis, ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2, S TNM stage, G histological grade