Table 1 Top 50 DEG genes, 25 upregulated and 25 downregulated, between the paired colorectal adenocarcinoma and adenoma samples (presented by FC)

SFRP4

NM_003014.3

secreted frizzled-related protein 4

4.51

0.00072

SIM2

NM_005069.3

single-minded family bHLH transcription factor 2

4.26

7.63E-07

EREG

NM_001432.2

epiregulin

3.54

0.01111

FAP

NM_001291807.1

fibroblast activation protein, alpha

3.34

0.00112

COL11A1

NM_001190709.1

collagen, type XI, alpha 1

3.09

0.00228

FUT1

NM_000148.3

fucosyltransferase 1

3.04

0.00017

ESM1

NM_001135604.1

endothelial cell-specific molecule 1

2.98

0.00060

FABP6

NM_001040442.1

fatty acid binding protein 6, ileal

2.95

0.00420

IL8

NM_000584.3

interleukin 8

2.94

0.02829

OSM

NM_020530.4

oncostatin

2.87

0.00913

IL6

NM_000600.3

interleukin 6

2.76

0.03991

COL1A1

NM_000088.3

collagen, type I, alpha 1

2.75

0.00181

STC2

NM_003714.2

stanniocalcin 2

2.74

0.00060

TDO2

NM_005651.3

tryptophan 2,3-dioxygenase

2.69

0.00264

OTX1

NM_001199770.1

orthodenticle homeobox 1

2.68

0.01271

WNT2

NM_003391.2

wingless-type MMTV integration site family member 2

2.65

0.00601

CTHRC1

NM_001256099.1

collagen triple helix repeat containing 1

2.51

0.00401

COL8A1

NM_001850.4

collagen, type VIII, alpha 1

2.50

0.00706

NOX4

NM_001143836.2

NADPH oxidase 4

2.49

0.00154

TNFAIP6

NM_007115.3

tumor necrosis factor, alpha-induced protein 6

2.48

0.00776

INHBA

NM_002192.2

inhibin, beta A

2.47

0.00594

CYR61

NM_001554.4

cysteine-rich, angiogenic inducer, 61

2.41

0.01300

GREM1

NM_001191322.1

gremlin 1, DAN family BMP antagonist

2.40

0.03523

CXCL10

NM_001565.3

chemokine (C-X-C motif) ligand 10

2.40

0.01026

ETV4

NM_001079675.2

ets variant 4

2.19

0.00060

CLCA1

NM_001285.3

chloride channel accessory 1

−7.97

0.00155

DEFA5

NM_021010.1

defensin, alpha 5, Paneth cell-specific

−6.31

0.00844

ITLN1

NM_017625.2

intelectin 1

−6.29

0.00668

ZG16

NM_152338.3

zymogen granule protein 16

−5.90

0.01116

DEFA6

NM_001926.3

defensin, alpha 6, Paneth cell-specific

−5.89

0.01083

FCGBP

NM_003890.2

Fc fragment of IgG binding protein

−4.68

0.00706

RETNLB

NM_032579.2

resistin like beta

−4.33

0.00060

ITLN2

NM_080878.2

intelectin 2

−4.26

0.00391

FAM55D

NM_001077639.1

neurexophilin and PC-esterase domain family, member 4

−4.12

0.00392

HEPACAM2

NM_001039372.2

HEPACAM family member 2

−4.05

0.00131

B3GNT6

NM_138706.4

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6

−4.03

0.00177

BEST2

NM_017682.2

bestrophin 2

−3.86

0.00099

REG4

NM_001159352.1

regenerating islet-derived family member 4

−3.81

0.04009

UGT2B17

NM_001077.3

UDP glucuronosyltransferase 2 family, polypeptide B17

−3.71

0.00601

SPINK4

NM_014471.1

serine peptidase inhibitor, Kazal type 4

−3.68

0.03954

DPP10-AS1

NR_036580.1

DPP10 antisense RNA 1

−3.67

0.01926

SLC4A4

NM_001098484.2

solute carrier family 4

−3.63

0.01004

UGT2B15

NM_001076.3

UDP glucuronosyltransferase 2 family polypeptide B15

−3.56

0.00500

KLK12

NM_019598.2

kallikrein-related peptidase 12

−3.56

0.00633

L1TD1

NM_001164835.1

LINE-1 type transposase domain containing 1

−3.52

0.02738

ADH1A

NM_000667.3

alcohol dehydrogenase 1A (class I) alpha polypeptide

−3.48

0.00852

PLA2G2A

NM_000300.3

phospholipase A2, group IIA (platelets synovial fluid)

−3.43

0.01981

VSIG2

NM_014312.3

V-set and immunoglobulin domain containing 2

−3.43

0.00681

ADH1C

NM_000669.4

alcohol dehydrogenase 1C (class I), gamma polypeptide

−3.39

0.00776

MB

NM_005368.2

myoglobin

−3.25

0.00144