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Table 3 Multivariate Analysis of Survival after Salvage Treatment in Grade 4 rHGG Patients

From: Safety and efficacy of Hypofractionated stereotactic radiosurgery for high-grade Gliomas at first recurrence: a single-center experience

Factors Comparison HR 95%CI P
Age, years Continuous 1.03 0.98–1.08 0.250
KPS > 70 v ≤ 70 0.13 0.03–0.56 0.006
PTV, cm3 > 10 v ≤ 10 0.44 0.13–1.50 0.187
BED, Gy > 37.5 v ≤ 37.5 1.50 0.53–4.27 0.446
Concurrent bevacizumab Yes v no 0.15 0.04–0.56 0.004
  1. Abbreviations: HR hazard ratio, CI confidence interval, KPS Karnofsky performance status, PTV planning target volume, BED biologically effective dose
  2. *BED was calculated using the LQ model with an alpha/beta ratio of 10
  3. †Concurrent was defined as bevacizumab administered with HSRS