Safety and efficacy of Hypofractionated stereotactic radiosurgery for high-grade Gliomas at first recurrence: a single-center experience

Table 3 Multivariate Analysis of Survival after Salvage Treatment in Grade 4 rHGG Patients

Factors	Comparison	HR	95%CI	P
Age, years	Continuous	1.03	0.98–1.08	0.250
KPS	> 70 v ≤ 70	0.13	0.03–0.56	0.006
PTV, cm³	> 10 v ≤ 10	0.44	0.13–1.50	0.187
BED, Gy	> 37.5 v ≤ 37.5	1.50	0.53–4.27	0.446
Concurrent^† bevacizumab	Yes v no	0.15	0.04–0.56	0.004

Abbreviations: HR hazard ratio, CI confidence interval, KPS Karnofsky performance status, PTV planning target volume, BED biologically effective dose
*BED was calculated using the LQ model with an alpha/beta ratio of 10
†Concurrent was defined as bevacizumab administered with HSRS

ISSN: 1471-2407