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Table 1 Baseline Characteristics of All Patients (N = 70)

From: Safety and efficacy of Hypofractionated stereotactic radiosurgery for high-grade Gliomas at first recurrence: a single-center experience

Parameter N %
Gender
 Male 40 57
 Female 30 43
Age, years
 Median 53 /
 Range 20–76 /
Initial histological WHO grade
 3 21 30
 4 49 70
Interval between HSRS and initial diagnosis (months)
 Median 13.7 /
 Range 1.1–55.3 /
KPS before salvage HSRS
 Median 70 /
 Range 40–90  
MGMT
 Unmethylated 25 36
 Methylated 9 13
 Unknown 36 51
IDH1 mutation
 Yes 5 7
 No 45 64
 Unknown 20 29
1p19q codeletion
 Yes 1 1
 No 25 36
 Unknown 44 63
Planning tumour volume (cm3)
 Median 16.68 /
 Range 0.81–121.96 /
Concurrent systemic therapy
 TMZ 14 20
 BVZ 28 40
 TMZ + BVZ 7 10
 BSC 21 30
Total 70 100
  1. Abbreviations: WHO World Health Organization, HSRS hypofractionated stereotactic radiosurgery, KPS Karnofsky performance status, MGMT O6-methylguanine-DNA methyltransferase, IDH1 Isocitrate dehydrogenase 1, TMZ Temozolomide, BVZ Bevacizumab, BSC best supportive care