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Table 2 Cox regression analysis on randomized untreated patients. Univariate and multivariable interaction analysis on breast cancer-specific survival evaluating various prognostic parameters for relative risk estimation for the untreated patient cohort. Multivariable model adjusted for grade, lymph node status, tumor size, age, ERα and HER2 status, in addition to the progranulin/sortilin scoring combination. HR: hazard ratio, CI: confidence interval, LN: lymph node, ERα: estrogen receptor alpha, HER2: human epidermal growth factor receptor 2

From: Tumor co-expression of progranulin and sortilin as a prognostic biomarker in breast cancer

Variable Univariate analysis Multivariable analysis
HR 95% CI p HR 95% CI p
Grade
 I-II 1    1   
 III 1.741 1.210–2.504 0.003 1.737 1.054–2.860 0.030
LN status
 LN negative 1    1   
 LN positive 1.964 1.244–3.101 0.004 2.250 1.348–3.758 0.002
Tumor size
 Continuous (mm) 1.014 0.997–1.032 0.108 1.020 0.999–1.041 0.059
Age
 Continuous (per year) 0.966 0.936–0.997 0.033 0.968 0.934–1.003 0.077
ERα
 ERα negative 1    1   
 ERα positive 0.824 0.525–1.294 0.401 1.259 0.678–2.340 0.466
HER2
 HER2 negative 1    1   
 HER2 positive 1.376 0.849–2.230 0.195 1.152 0.648–2.046 0.629
Progranulin/sortilin combination
 Mixed 1    1   
 Double high progranulin/sortilin 1.922 1.224–3.017 0.005 2.188 1.317–3.637 0.003