Table 2 Comparison of the incidence of key drug-related grade ≥3 AEs at final follow-up

Anaemia

9 (12.2)

8 (10.5)

0.752

Aspartate aminotransferase increased

5 (6.8)

0 (0.0)

0.021^a

Colonic perforation

0 (0.0)

1 (1.3)

1.000

Creatinine increased

2 (2.7)

2 (2.6)

0.978

Dehydration

3 (4.1)

1 (1.3)

0.298

Dyspnoea

6 (8.1)

0 (0.0)

0.011^a

Hyponatraemia

9 (12.2)

1 (1.3)

0.008^a

Hypotension

8 (10.8)

0 (0.0)

0.003^a

Vaginal fistula

3 (4.1)

0 (0.0)

0.076

Lipases increased

4 (5.4)

4 (5.3)

0.969

Lung infection

3 (4.1)

3 (3.9)

0.973

Nausea

4 (5.4)

2 (2.6)

0.386

Nervous system disorders

8 (10.8)

1 (1.3)

0.014^a

Skin infection

3 (4.1)

0 (0.0)

0.076

Urinary tract infection

4 (5.4)

0 (0.0)

0.040^a

≥ 2 AEs in one patient

23 (31.1)

12 (15.8)

0.027^a